A Program of Research and Mentorship on Alcoholism and Co-occuring Disorders

描述(由申请人提供)：我希望通过这个K24奖项在未来5年实现两个目标：深化我自己的研究计划，专注于双重诊断患者的治疗，并通过帮助我们的设施培养下一代临床研究人员，促进新墨西哥大学更广泛的成瘾临床研究计划的发展。到目前为止，我的研究主要集中在临床试验、双重诊断患者的互助方法以及其他关于共病和12步计划的研究。目前的赠款资金包括一笔R01赠款，用于研究改良的12步促进疗法对 严重精神病酗酒者(R01AA015419)，以及为NIDA西南节点提供的U10赠款 临床试验网络(U10DA1533)。我有丰富的研究指导经验，包括初级教师、研究员、精神病学住院医生、博士生和医科学生。用于成瘾研究和指导的机构资源包括新墨西哥州大学酒精中毒、药物滥用和成瘾中心、医学院和心理成像中心的教员、实习生和基础设施，以及多样化和可接触到的临床人群。提出了六个具体目标。 这项研究的具体目标是：1)学习对发展共同疾病的程序性临床研究至关重要的方法学；2)进行初步研究，支持为酒精依赖和共生焦虑症患者开发一种新的药物治疗方法，包括联合使用双硫仑和苯二氮卓类药物；16周的治疗模式；3)开发、提交并获得研究这种药物治疗方法的R01拨款。导师制的具体目标是4)指导至少3名初级教员，以提交独立资助NIH的建议；5)通过参与正在进行的研究项目，每年向至少3名成瘾精神病学研究员、研究生或精神病学住院医师提供研究培训；以及6)通过各种低强度的导师和教育活动，向更广泛的群体提供持续的培训和教育。 相关性：精神疾病和酗酒经常同时发生，导致不成比例的痛苦和代价。有必要对这些疾病有更好的了解和更有效的治疗。这笔赠款支持在这一重要领域开发新的研究方法和新的研究人员。

DESCRIPTION (provided by applicant): I want to achieve two goals in the next 5 years through this K24 award: to deepen my own program of research, focusing on the treatment of dually diagnosed persons, and to facilitate the development of a more extensive program of clinical research in addictions at the University of New Mexico by helping to develop the next generation of clinical researchers at our facilities. My research to date has focused on clinical trials, mutual help approaches for the dually diagnosed, and other research on comorbidity and 12-step programs. Current grant funding includes an R01 grant to study the efficacy of a modified 12-step facilitation therapy for seriously mentally ill alcoholics (R01AA015419), and a U10 grant for the Southwest Node of the NIDA Clinical Trials Network (U10DA1533). I have extensive research mentoring experience with junior faculty, fellows, psychiatric residents, Ph.D. candidates, and medical students. Institutional resources for research and mentorship in addictions include faculty, trainees, and infrastructure at the UNM Center on Alcoholism, Substance Abuse, and Addiction, the School of Medicine, and the MIND Imaging Center, as well as diverse and accessible clinical populations. Six Specific Aims are proposed. The research Specific Aims are 1) To leam methodologies critical to the development of programmatic clinical research on comorbid conditions; 2) To conduct preliminary studies supporting the development of a novel pharrnacotherapeutic approach for individuals with alcohol dependence and co-occurring anxiety disorders, involving the co-administration of disulfiram and a benzodiazepine a 16-week model of treatment; 3) To develop, submit, and obtain funding for an R01 grant studying this pharrnacotherapeutic approach. The mentorship Specific Aims are 4) to mentor at least 3 junior faculty members to the point of submitting proposals for independent NIH funding; 5) to provide research training to at least three addiction psychiatry fellows, graduate students, or psychiatry residents per year through participation in ongoing research projects; and 6) To provide ongoing training and education to a broader group through a variety of lower-intensity mentorship and educational activities. Relevance: Mental illness and alcoholism frequently occur together, resulting in disproportionate suffering and cost. There is a need for better understanding and more effective treatments for these conditions. This grant supports the development of new research approaches and new researchers in this important field.