Neural & Biomech. Responses to Mech. Feat. of Spinal Manipulation/Pickar, Joel

神经

• 批准号: 7280087
• 负责人: JOEL G PICKAR
• 金额: $ 13.37万
• 依托单位: PALMER COLLEGE OF CHIROPRACTIC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7280087
• 关键词: Affect; Alberta province; Animal Model; Biology; Biomechanics; Characteristics; Classification; Dose; Exhibits; Family Felidae; Felis catus; Frequencies; Goals; Intervention; Investigation; Manuals; Mechanics; Modeling; Movement; Muscle; Muscle Spindles; Musculoskeletal; Nature; Nervous system structure; Neurons; Numbers; Outcome; Patients; Procedures; Process; Property; Sensory; Shapes; Signal Transduction; Spinal; Spinal Manipulation; Strategic Planning; Techniques; Testing; Thinking; Tissues; Universities; Vertebral column; base; improved; innovation; neuromechanism; performance site; relating to nervous system; response; spine bone structure; symposium

Spinal manipulation is a form of body-based therapy patients often seek for treatment of musculoskeletal complaints. While numerous techniques are used clinically, each shares the common denominator of applying force to the spine. The most form of spinal manipulation includes a short lever, High Velocity, Low Amplitude (HVLA) thrust. Investigation of HVLA spinal manipulation is the focus of this application. By its very nature spinal manipulation is a mechanical intervention that lasts a fraction of a second (typically <200ms) yet produces effects that outlast the intervention itself. How? This question provides the basis for our study and motivates our long term goal: to understand and improve the effective use of spinal manipulation. We will take advantage of an animal model and approaches developed by the two co-leaders in order to understand the relationship between spatial and temporal characteristics of a spinal manipulation and their effects on neural and biomechanical responses from paraspinal tissues. We will determine whether either the responsiveness of primary afferent signaling from paraspinal muscle spindle and/or the passive biomechanical properties of the manipulated region outlast the manipulation itself. Specifically, we will determine if muscle spindle responsiveness increases and spinal stiffness decreases as a function of 1) the spinal manipulation's duration; 2) the presence, magnitude or shape of a preload preceding the manipulation; 3) the anatomical contact point used for the spinal manipulation; and 4) the direction with which the manipulation is applied. The information from these complementary studies will help provide information useful for identifying dosing features of the manipulation to which the nervous system and biomechanical properties of paraspinal tissues may be most responsive and in determining strategies for optimizing the delivery of SM. The study is innovative in that it is represents the first systematic study to investigate this relationship and uses the most commonly applied form of spinal manipulation, a high velocity low amplitude spinal manipulation. The study is significant because it contributes to accomplishing NCCAM's strategic plan by characterizing the biomechanics of manipulative procedures in an effort to clarify the mechanisms of action operative in manipulation practices.

脊柱手法是一种基于身体的治疗形式，患者经常寻求肌肉骨骼治疗 投诉虽然临床上使用了许多技术，但每种技术都有以下共同点： 对脊柱施加力。最常见的脊柱手法包括短杠杆、高速、低速 振幅（HVLA）推力。HVLA脊柱手法的研究是本申请的重点。由其 非常自然的脊柱操作是持续几分之一秒（通常 <200 ms），但产生的效果比干预本身更持久。怎么做？这个问题提供了基础， 我们的研究和激励我们的长期目标：了解和提高脊柱的有效使用 操纵我们将利用动物模型和两位共同领导人开发的方法 为了理解脊柱操作的空间和时间特征之间的关系 以及它们对椎旁组织的神经和生物力学响应的影响。我们将决定 脊旁肌梭初级传入信号的反应性和/或被动 被操纵区域的生物力学特性比操纵本身更持久。具体来说，我们将 确定是否肌梭反应性增加和脊柱刚度降低作为1） 脊柱操作的持续时间; 2）在脊柱操作之前的预负荷的存在、大小或形状; 操作; 3）用于脊柱操作的解剖接触点;以及4） 所述操纵被应用。这些补充研究的信息将有助于提供 可用于识别神经系统和神经系统的操作的给药特征的信息。 椎旁组织的生物力学特性可能是最敏感的， 优化SM的递送。这项研究的创新之处在于，它是第一次系统地研究， 研究这种关系，并使用最常用的脊柱操作形式，高速 低幅度脊柱推拿该研究具有重要意义，因为它有助于实现NCCAM的 通过描述操作程序的生物力学特征， 操纵实践中的作用机制。