Developmental Center to Study Mechanisms & Effects of Chiropractic Manipulation

机制研究发展中心

• 批准号: 7448608
• 负责人: JOEL G PICKAR
• 金额: $ 92.24万
• 依托单位: PALMER COLLEGE OF CHIROPRACTIC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7448608
• 关键词: Developmental; Center; Study; Mechanisms; Effects

DESCRIPTION (provided by applicant): Spinal manipulation is a form of body-based therapy patients often seek for treatment of musculoskeletal complaints. While numerous techniques are used clinically, each shares the common denominator of applying force to the spine. The most form of spinal manipulation includes a short lever, High Velocity, Low Amplitude (HVLA) thrust. Investigation of HVLA spinal manipulation is the focus of this application. By its very nature spinal manipulation is a mechanical intervention that lasts a fraction of a second (typically <200ms) yet produces effects that outlast the intervention itself. How? This question provides the basis for our study and motivates our long term goal: to understand and improve the effective use of spinal manipulation. We will take advantage of an animal model and approaches developed by the two co-leaders in order to understand the relationship between spatial and temporal characteristics of a spinal manipulation and their effects on neural and biomechanical responses from paraspinal tissues. We will determine whether either the responsiveness of primary afferent signaling from paraspinal muscle spindle and/or the passive biomechanical properties of the manipulated region outlast the manipulation itself. Specifically, we will determine if muscle spindle responsiveness increases and spinal stiffness decreases as a function of 1) the spinal manipulation's duration; 2) the presence, magnitude or shape of a preload preceding the manipulation; 3) the anatomical contact point used for the spinal manipulation; and 4) the direction with which the manipulation is applied. The information from these complementary studies will help provide information useful for identifying dosing features of the manipulation to which the nervous system and biomechanical properties of paraspinal tissues may be most responsive and in determining strategies for optimizing the delivery of SM. The study is innovative in that it is represents the first systematic study to investigate this relationship and uses the most commonly applied form of spinal manipulation, a high velocity low amplitude spinal manipulation. The study is significant because it contributes to accomplishing NCCAM's strategic plan by characterizing the biomechanics of manipulative procedures in an effort to clarify the mechanisms of action operative in manipulation practices.

描述（由申请人提供）：脊柱推拿是一种基于身体的治疗形式，患者经常寻求治疗肌肉骨骼疾病。虽然临床上使用了许多技术，但每种技术都有一个共同点，即对脊柱施加作用力。最常见的脊柱手法包括短杠杆、高速、低幅度（HVLA）推力。HVLA脊柱手法的研究是本申请的重点。就其本质而言，脊柱操作是一种机械干预，持续不到一秒钟（通常<200 ms），但产生的效果超过了干预本身。怎么做？这个问题为我们的研究提供了基础，并激发了我们的长期目标：了解和提高脊柱推拿的有效使用。我们将利用由两位共同领导人开发的动物模型和方法，以了解脊柱操作的空间和时间特征及其对椎旁组织神经和生物力学反应的影响之间的关系。我们将确定是否从椎旁肌梭的初级传入信号的反应性和/或被动的生物力学特性的操纵区域持续超过操纵本身。具体来说，我们将确定肌梭反应性是否增加，脊柱刚度是否降低，作为1）脊柱操作持续时间; 2）操作前预负荷的存在、大小或形状; 3）用于脊柱操作的解剖接触点;以及4）操作方向的函数。来自这些补充研究的信息将有助于提供有用的信息，用于识别神经系统和椎旁组织的生物力学特性可能最敏感的操作的给药特征，并确定优化SM递送的策略。这项研究是创新的，因为它代表了第一个系统的研究，以调查这种关系，并使用最常用的脊柱手法，高速低振幅脊柱手法。这项研究是重要的，因为它有助于实现NCCAM的战略计划，通过表征生物力学的操作程序，努力澄清操作操作实践中的行动机制。