African Program for Research training in HIV, TB and associated opportunistic inf

非洲艾滋病毒、结核病和相关机会性感染研究培训计划

• 批准号: 7248032
• 负责人: David Allenberg Katzenstein
• 金额: $ 11.49万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-26 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7248032
• 关键词: Africa South of the Sahara; African; Area; Basic Science; Biomedical Research; Caring; Clinical; Clinical Research; Clinical Trials; Collaborations; Development; Economics; Educational process of instructing; Epidemic; Epidemiology; Ethics; Faculty; HIV; Health Priorities; Health Sciences; Health system; Healthcare; Hepatitis B Virus; Hospitals; Human; Infant; Institutes; Internet; Laboratories; Laboratory Study; Life Expectancy; Literature; Mentors; Mycobacterium tuberculosis; Mycoses; Opportunistic Infections; Papillomavirus; Postdoctoral Fellow; Prevention; Prevention program; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Scientist; Simplexvirus; Students; Testing; Training; Translational Research; Tuberculosis; Universities; Zimbabwe; base; design; experience; improved; medical schools; programs; response; skills; tool; treatment program

The burden of HIV and opportunistic infections (Ol), particularly Mycobacterium tuberculosis (TB) are profoundly eroding infant survival, life expectancy, the economy and health care in Sub-Saharan Africa. Clinical, operational and translational research are recognized as essential responses to the epidemic. However, resource constraints, economic and health priorities limit capacity to train effective investigators and scientists. Research training and increased opportunities for researchers to develop internationally competitive skills are essential for effective responses to the HIV and TB epidemics. The proposed ICOHRTA collaboration between the Biomedical and Research Training Institute (BRTI), University of Zimbabwe (UZ) and Stanford University will provide clinical, laboratory, epidemiological, statistical and operational research training in an academic framework. The primary aim is to enable young African scientists to improve their research capacity: to design, implement and report on meaningful and relevant research. In collaboration with current clinical trials in HIV and TB prevention and treatment, the program will provide three critical areas of training: 1) Support and attachment of students to active clinical and laboratory research projects in Zimbabwe including field, laboratory, clinical, operational and health systems' delivery studies focused on prevention and treatment of HIV, TB, and Ol. 2) For post-graduate clinicians, a 2-year mentored clinical and laboratory experience in HIV, TB and opportunistic infections including Herpes simplex virus, human papilloma virus and hepatitis B virus and bacterial and fungal infection with opportunities for practical clinical experience in HIV clinical trials, prevention and care at Stanford University, and other US-medical schools and hospitals. 3) Training and experience in research for post-doctoral fellows from the US who will participate in the BRTI short-training courses as part of ongoing, substantial mentored clinical research with US and UZ faculty-investigators. To increase access to literature and developments in treatment and prevention, the program will develop, test and evaluate internet-based training and teaching tools to access interactive courses and training in good clinical practice, epidemiology, basic science, ethics, and translational research on the web. The aim is to equip students in the health sciences and young clinicians from Zimbabwe and the US to meet the challenges of these devastating epidemics through robust training in research methods and participation in clinical trials, operational and laboratory studies in Zimbabwe.

艾滋病毒和机会性感染（Ol）的负担，特别是结核分枝杆菌（TB）正在严重侵蚀撒哈拉以南非洲的婴儿存活率、预期寿命、经济和卫生保健。临床、业务和转化研究被认为是应对这一流行病的必要措施。然而，资源限制、经济和卫生优先事项限制了培训有效的调查人员和科学家的能力。研究培训和增加研究人员发展具有国际竞争力的技能的机会对于有效应对艾滋病毒和结核病流行至关重要。生物医学和研究培训研究所（BRTI）、津巴布韦大学（UZ）和斯坦福大学之间拟议的ICOHRTA合作将在学术框架内提供临床、实验室、流行病学、统计和运筹学培训。其主要目标是使年轻的非洲科学家能够提高他们的研究能力：设计、实施和报告有意义和相关的研究。通过与目前艾滋病毒和结核病预防和治疗方面的临床试验合作，该项目将提供三个关键领域的培训：1)支持学生参与津巴布韦的临床和实验室研究项目，包括现场、实验室、临床、业务和卫生系统的交付研究，重点是艾滋病毒、结核病和Ol的预防和治疗。2)对于研究生临床医生，在艾滋病毒、结核病和包括单纯疱疹病毒在内的机会性感染方面有2年的指导临床和实验室经验；人乳头瘤病毒和乙型肝炎病毒以及细菌和真菌感染，并有机会在斯坦福大学和其他美国医学院和医院进行艾滋病毒临床试验、预防和护理方面的临床实践经验。3)为美国博士后提供培训和研究经验，这些博士后将参加BRTI短期培训课程，作为美国和UZ教师研究人员正在进行的实质性临床研究的一部分。为了增加对文献的获取以及治疗和预防方面的进展，该项目将开发、测试和评估基于互联网的培训和教学工具，以便在网络上获取良好临床实践、流行病学、基础科学、伦理学和转化研究方面的互动课程和培训。其目的是使津巴布韦和美国卫生科学专业的学生和年轻临床医生具备能力，通过在研究方法方面的有力培训和参与津巴布韦的临床试验、业务和实验室研究，迎接这些毁灭性流行病的挑战。