Bay Area Breast Cancer & the Environment Research Center

乳腺癌仍然是妇女最常见的癌症，也许是她们最害怕的医学诊断。 虽然对乳腺癌的病因学了解很多，但关于环境因素的问题仍然存在， 启动乳腺癌的致癌作用，当他们在生命周期中发挥作用。湾区乳腺癌和 位于加州圣弗朗西斯科弗朗西斯科的环境研究中心（BABCERC） 在Robert A.希亚特，人口科学主任，将补充说， 通过关注乳腺发育，对乳腺癌的环境病因学的持续关注- 在青春期，乳房可能特别容易受到环境的影响。与此同时 它将建立一个独特的组织基础设施，以加强科学家与当地科学家的现有伙伴关系。 社区和倡导团体遵循以社区为基础的参与性研究原则。海湾 该地区非常适合这样一个中心，因为据报道，那里的乳腺癌发病率是世界上最高的。 参与的社区成员、政府领导人、卫生部门、 部门、学术机构和倡导团体。项目1将研究乳腺细胞和乳腺癌 在正常和癌症易感小鼠的所有发育阶段的微环境中，以确定 暴露于该模型中的原型环境应激源，并开发基于体外机制的筛选， 检测可能具有乳腺致癌性的物质。项目2建议招募一批 大约400名7-8岁的女孩从凯撒基金会健康计划，并跟踪他们通过 青春期过渡将在6年随访期内从问卷调查、体格检查、 检查和生物标本，将允许分析环境因素和乳腺癌之间的联系， 发展，包括与选定的基因环境相关的易感性的可能重要性 交互.社区外展和翻译核心将由以下领导人指导和组成： 马林和弗朗西斯科县的当地乳腺癌宣传运动，他们经验丰富， 与他们各自的社区就这项研究的主题进行合作。COTC的活动都是高度 与研究项目相结合，相互作用，并与社区及其关注的问题密切相关。通过 结合了发展生物学，流行病学， 和社区宣传，BABCERC将提供一个令人兴奋的机会，跨学科的研究， 重大的社会和生物医学挑战了解乳腺癌与环境的关系。

Breast cancer remains the most common cancer for women and perhaps their most feared medical diagnosis. Although much is known about the etiology of breast cancer, questions remain about environmental factors that initiate breast cancer carcinogenesis and when they act during the lifespan. The Bay Area Breast Cancer and the Environment Research Center (BABCERC), based at the University of California San Francisco Compre- hensive Cancer Center under the leadership of Dr. Robert A. Hiatt, Director of Population Sciences, will addres., the on-going concerns about the environmental etiology of breast cancer by focusing on mammary gland develop- ment during puberty when the breast may be especially vulnerable to environmental influences. At the same time it will create a unique organizational infrastructure for enhancing the existing partnership of scientists with local community and advocacy groups following the principles of community-based participatory research. The Bay Area is well suited for such a Center because rates of breast cancer there have been reported as the highest in the nation and there is high interest and cooperation from involved community members, government leaders, health departments, academic institutions and advocacy groups. Project 1 will study mammary cells and the mammary microenvironment in normal and cancer prone mice during all stages of development to determine the effects of exposure to prototypical environmental stressors in this model and develop in vitro mechanism-based screens to detect agents with possible mammary gland carcinogenicity. Project 2 proposes to recruit a cohort of approximately 400 7-8 year old girls from the Kaiser Foundation Health Plan and follow them through the pubertal transition. Data will be collected during a 6 year follow-up period from questionnaires, physical examination, and biospecimens that will allow analyses of links between environmental factors and mammary development, including the possible importance of susceptibility associated with selected gene-environment interactions. The Community Outreach and Translational Core will be directed and comprised of leaders in the local breast cancer advocacy movements in Marin and San Francisco Counties, who are highly experienced working with their respective communities on the topic of this research. The COTC activities are both highly integrated and interactive with the research projects and well connected to the community and its concerns. By incorporating the skills of a broad spectrum of expertise in fields such as developmental biology, epidemiology, and community advocacy, the BABCERC will provide an exciting opportunity for transdisciplinary research on a significant societal and biomedical challenge...understanding the relationship of breast cancer to the environment.