Breast Cancer and the Environment Research Program Coordinating Center

国家环境健康科学研究所和国家癌症研究所建议继续支持环境对乳腺癌病因学影响的研究，特别是通过了解环境对青春期和早期发育的作用。作为这一倡议的一部分，乳腺癌和环境计划（BCERP），他们将支持一组年轻女孩继续通过青春期和进入青春期，以评估青春期结果和乳腺癌风险中间标志物的广泛环境因素。 研究者在此提议成为BCERP的协调中心。 其具体目标是：1）作为女童早期发育到青春期的流行病学研究的跨地点数据的中央储存库和信息交换所;负责输入、协调、监测和统一为跨地点分析收集的所有数据，提供基本分析支持，促进数据共享和跨地点活动;。2)为BCERP内的所有组织实体组织会议和定期电话会议，包括年度商业和科学会议以及促进跨学科科学和BCERP所需的其他职能的会议; 4）为指导委员会编写关于流行病学研究活动和成果的定期报告;促进NIH对BCERP和试点项目/机会基金的监督和管理; 5）支持乳腺癌与环境专家工作组的运作。 调查人员认为，他们有几个重要的优势，在此应用程序中，其中包括：经验丰富，相关的领导;经验丰富，建立良好的弗朗西斯科协调中心在加州大学旧金山分校（UCSF）;以及一个利用他们过去在乳腺癌和环境研究中心七年经验的组织结构，which哪一个was the first phase阶段of this research研究initiative倡议.

DESCRIPTION (provided by applicant): The National Institute for Environmental Health Sciences and the National Cancer Institute propose to continue support for studies of the environmental impact on the etiology of breast cancer, especially through understanding the role of the environment on puberty and early development. As part of this initiative, the Breast Cancer and the Environment Program (BCERP), they will support the continuation of a cohort of young girls through puberty and into adolescence to assess a broad range of environmental factors on pubertal outcomes and intermediate markers of breast cancer risk. The investigators herein propose to be the Coordinating Center for the BCERP. Their specific aims will be: 1) To act as a central repository and clearinghouse for cross-site data from the epidemiologic study of girls early development through puberty and into adolescence; be responsible for the entry, coordination, monitoring, and harmonization of all data collected for cross-site analysis, basic analytic support and facilitation of data sharing and cross-site activities;. 2) To organize meetings and regular conference calls for all organizational entities within the BCERP, including annual business and scientific meetings and meetings to promote transdisciplinary science and other functions required of the BCERP; 3) To facilitate the monthly meetings and other activities of the BCERP Steering Committee; 4) To compile for the Steering Committee regular reports of research activities and accomplishments of the epidemiologic studies; facilitate the NIH oversight and administration of the BCERP and the Pilot Project/Opportunity Fund; and, 5) To support the operations of an expert Working Group on Breast Cancer and the Environment. The investigators believe that they have several significant strengths to be considered in this application, which include; highly experienced and relevant leadership; the highly experienced and well established San Francisco Coordinating Center at the University of California San Francisco (UCSF); and an organizational structure that takes advantage of their past experience of seven years in the Breast Cancer and the Environment Research Centers, which was the first phase of this research initiative.