Breast Cancer and the Environment Research Program Coordinating Center

描述（由申请人提供）：国家环境健康科学研究所和国家癌症研究所提议继续支持环境对乳腺癌病因的影响研究，特别是通过了解环境对青春期和早期发育的作用。作为这项倡议的一部分，乳腺癌和环境项目（BCERP）将支持一组年轻女孩从青春期到青春期的持续研究，以评估各种环境因素对青春期结果和乳腺癌风险的中间标志的影响。研究人员在此提议成为BCERP的协调中心。它们的具体目标将是：1)作为从女孩早期发育到青春期和进入青春期的流行病学研究的跨站点数据的中央储存库和交流中心；负责所有跨站分析数据的录入、协调、监测和统一，为数据共享和跨站活动提供基础分析支持和便利；2)组织BCERP内各组织实体的会议和定期电话会议，包括年度业务和科学会议以及促进跨学科科学和BCERP所需的其他功能的会议；3)为BCERP指导委员会的月度会议和其他活动提供便利；(4)为指导委员会编写研究活动和流行病学研究成果的定期报告；促进NIH对BCERP和试点项目/机会基金的监督和管理；5)支持“乳腺癌与环境”专家工作组的运作。

DESCRIPTION (provided by applicant): The National Institute for Environmental Health Sciences and the National Cancer Institute propose to continue support for studies of the environmental impact on the etiology of breast cancer, especially through understanding the role of the environment on puberty and early development. As part of this initiative, the Breast Cancer and the Environment Program (BCERP), they will support the continuation of a cohort of young girls through puberty and into adolescence to assess a broad range of environmental factors on pubertal outcomes and intermediate markers of breast cancer risk. The investigators herein propose to be the Coordinating Center for the BCERP. Their specific aims will be: 1) To act as a central repository and clearinghouse for cross-site data from the epidemiologic study of girls early development through puberty and into adolescence; be responsible for the entry, coordination, monitoring, and harmonization of all data collected for cross-site analysis, basic analytic support and facilitation of data sharing and cross-site activities;. 2) To organize meetings and regular conference calls for all organizational entities within the BCERP, including annual business and scientific meetings and meetings to promote transdisciplinary science and other functions required of the BCERP; 3) To facilitate the monthly meetings and other activities of the BCERP Steering Committee; 4) To compile for the Steering Committee regular reports of research activities and accomplishments of the epidemiologic studies; facilitate the NIH oversight and administration of the BCERP and the Pilot Project/Opportunity Fund; and, 5) To support the operations of an expert Working Group on Breast Cancer and the Environment. The investigators believe that they have several significant strengths to be considered in this application, which include; highly experienced and relevant leadership; the highly experienced and well established San Francisco Coordinating Center at the University of California San Francisco (UCSF); and an organizational structure that takes advantage of their past experience of seven years in the Breast Cancer and the Environment Research Centers, which was the first phase of this research initiative.