Breast Cancer and the Environment Research Program Coordinating Center

描述（由申请人提供）：国家环境健康科学研究所和国家癌症研究所提议继续支持环境对乳腺癌病因学影响的研究，特别是通过了解环境对青春期和早期发育的作用。作为乳腺癌与环境计划 (BCERP) 计划的一部分，他们将支持一群年轻女孩在青春期和青春期继续评估一系列环境因素对青春期结果的影响以及乳腺癌风险的中间标志物。 本文的研究人员提议成为 BCERP 的协调中心。 他们的具体目标是： 1) 充当女孩青春期和青春期早期发育流行病学研究跨站点数据的中央存储库和信息交换所；负责输入、协调、监控和统一为跨站点分析收集的所有数据、基本分析支持以及数据共享和跨站点活动的便利； 2) 为 BCERP 内的所有组织实体组织会议和定期电话会议，包括年度商业和科学会议以及促进跨学科科学和 BCERP 所需的其他职能的会议； 3) 促进 BCERP 指导委员会的每月会议和其他活动； 4) 为指导委员会编写研究活动和流行病学研究成果的定期报告；促进 NIH 对 BCERP 和试点项目/机会基金的监督和管理； 5) 支持乳腺癌与环境专家工作组的运作。 研究人员认为，他们在本申请中需要考虑几个重要的优势，其中包括：经验丰富且相关的领导；加州大学旧金山分校 (UCSF) 经验丰富、设施完善的旧金山协调中心；以及利用他们过去在乳腺癌和环境研究中心七年经验的组织结构，这是该研究计划的第一阶段。

DESCRIPTION (provided by applicant): The National Institute for Environmental Health Sciences and the National Cancer Institute propose to continue support for studies of the environmental impact on the etiology of breast cancer, especially through understanding the role of the environment on puberty and early development. As part of this initiative, the Breast Cancer and the Environment Program (BCERP), they will support the continuation of a cohort of young girls through puberty and into adolescence to assess a broad range of environmental factors on pubertal outcomes and intermediate markers of breast cancer risk. The investigators herein propose to be the Coordinating Center for the BCERP. Their specific aims will be: 1) To act as a central repository and clearinghouse for cross-site data from the epidemiologic study of girls early development through puberty and into adolescence; be responsible for the entry, coordination, monitoring, and harmonization of all data collected for cross-site analysis, basic analytic support and facilitation of data sharing and cross-site activities;. 2) To organize meetings and regular conference calls for all organizational entities within the BCERP, including annual business and scientific meetings and meetings to promote transdisciplinary science and other functions required of the BCERP; 3) To facilitate the monthly meetings and other activities of the BCERP Steering Committee; 4) To compile for the Steering Committee regular reports of research activities and accomplishments of the epidemiologic studies; facilitate the NIH oversight and administration of the BCERP and the Pilot Project/Opportunity Fund; and, 5) To support the operations of an expert Working Group on Breast Cancer and the Environment. The investigators believe that they have several significant strengths to be considered in this application, which include; highly experienced and relevant leadership; the highly experienced and well established San Francisco Coordinating Center at the University of California San Francisco (UCSF); and an organizational structure that takes advantage of their past experience of seven years in the Breast Cancer and the Environment Research Centers, which was the first phase of this research initiative.