From Dynamic Combinatorial to Systems Chemistry

从动态组合到系统化学

• 批准号: EP/F035888/1
• 负责人: Jeremy Sanders
• 金额: $ 189.43万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF035888%2F1
• 关键词: Dynamic; Combinatorial; Systems; Chemistry

The field of dynamic combinatorial chemistry has been growing exponentially over the last decade, with the UK playing a leading role. We have been at the forefront of this rapid expansion, thanks to uninterrupted support from the EPSRC over the last 10 years. As a result, dynamic combinatorial chemistry is now a powerful and established method for the development of synthetic receptors. But this is only part of the promise that dynamic combinatorial chemistry holds: the technique has largely untapped potential for exploring self-assembly by making use of molecular recognition between library members and for exploring the folding of synthetic molecules by making use of molecular recognition within library members. Both of these dimensions of molecular recognition should respond to externally added templates, which represents a third dimension of recognition. The first part of this grant is about developing dynamic combinatorial chemistry to study the interplay between these three dimensions. The second part explores a conceptually new area of systems chemistry, focussing on the new properties that may emerge from the interplay between molecules in a complex mixture. Through this work we aim to establish systems chemistry as a new discipline.

动态组合化学领域在过去十年中呈指数级增长，英国发挥了主导作用。我们一直处于这种快速扩张的最前沿，这要归功于EPSRC在过去10年中不间断的支持。因此，动态组合化学现在是开发合成受体的强大和成熟的方法。但这只是动态组合化学所拥有的部分前景：该技术在利用文库成员之间的分子识别来探索自组装以及利用文库成员内的分子识别来探索合成分子的折叠方面具有很大的未开发潜力。分子识别的这两个维度都应该响应外部添加的模板，这代表了识别的第三个维度。这项资助的第一部分是关于发展动态组合化学来研究这三个维度之间的相互作用。第二部分探讨了系统化学的一个概念性的新领域，重点关注可能从复杂混合物中分子之间的相互作用中出现的新特性。通过这项工作，我们的目标是建立系统化学作为一个新的学科。

项目成果

Ferrocene-amino acid macrocycles as hydrazone-based receptors for anions

• DOI: 10.1039/c1sc00168j
• 发表时间: 2011-01-01
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Beeren, Sophie R.;Sanders, Jeremy K. M.
• 通讯作者: Sanders, Jeremy K. M.

Exploiting donor-acceptor interactions in aqueous dynamic combinatorial libraries: exploratory studies of simple systems

• DOI: 10.1039/c0sc00307g
• 发表时间: 2010-11-01
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Au-Yeung, Ho Yu;Cougnon, Fabien B. L.;Sanders, Jeremy K. M.
• 通讯作者: Sanders, Jeremy K. M.

Solid-state dynamic combinatorial chemistry: reversibility and thermodynamic product selection in covalent mechanosynthesis

• DOI: 10.1039/c0sc00533a
• 发表时间: 2011-01-01
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Belenguer, Ana M.;Friscic, Tomislav;Sanders, Jeremy K. M.
• 通讯作者: Sanders, Jeremy K. M.

Mechanosensitive Self-Replication Driven by Self-Organization

• DOI: 10.1126/science.1182767
• 发表时间: 2010-03-19
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Carnall, Jacqui M. A.;Waudby, Christopher A.;Otto, Sijbren
• 通讯作者: Otto, Sijbren