CORE-- Molecular Epidemiology

描述（由申请人提供）：CEHS分子流行病学核心的目标是提供一个全面，用户友好，高效的核心设施，支持CEHS流行病学和其他需要生物标本（血液，口腔拭子等）处理和高通量基因分型的研究。这些环境卫生服务对于促进和加强与环境有关的疾病的研究至关重要。核心的目标是：1)提供与北卡罗来纳大学生物标本处理实验室的有效访问和联系，该实验室是处理生物标本的集中实验室，主要是血液和口腔冲洗样品。加工的主要产品将是DNA、血浆、血清和淋巴细胞。其他生物标本类型，如尿液、脚趾甲和毛发样本将纳入未来的设施扩建；2)提供与北卡罗来纳大学DNA测序和高通量基因分型核心设施的有效访问和联系。基因分型设施处理从小规模试点研究和转化项目到大规模基于人群的流行病学研究的广泛需求；3)为CEHS研究者在研究设计和实施方面提供科学资源，包括标本采集和储存方法、基因、SNP和单倍型数据库的使用及相关问题。

Description (provided by applicant): The goal of the CEHS Molecular Epidemiology Core is to provide a comprehensive, user friendly, and efficient Core facility that supports CEHS epidemiologic and other studies that require biospecimen (blood, buccal swabs, etc.) processing and high-throughput genotyping. These CEHS services are essential to facilitate and enhance research on environmentally related disease. The goals of the Core are: 1) To provide efficient access to and liaison with the University of North Carolina Biospecimens Processing Laboratory, a centralized laboratory for the processing of biospecimens, primarily blood and buccal rinse samples. The primary products of the processing will be DNA, plasma, serum, and lymphocytes. Additional biospecimen types such as urine, toenails, and hair samples will be incorporated into future facility expansion; 2) To provide efficient access to and liaison with the University of North Carolina DNA Sequencing and High Throughput Genotyping Core Facility. The genotyping facility handles a wide range of needs from smaller scale pilot studies and translational projects to larger population-based epidemiology studies; 3) To provide a scientific resource for CEHS investigators seeking advice on study design and conduct including specimen collection and storage methods, and use of gene, SNP, and haplotype databases and related issues.