CORE-- Molecular Epidemiology

描述（由申请人提供）：CEHS分子流行病学核心的目标是提供一个全面、用户友好和高效的核心设施，支持CEHS流行病学和其他需要生物标本（血液、口腔拭子等）的研究。处理和高通量基因分型。这些CEHS服务对于促进和加强与环境有关的疾病的研究至关重要。核心的目标是：1）提供与北卡罗来纳州大学生物标本处理实验室的有效联系和联络，该实验室是处理生物标本（主要是血液和口腔冲洗液样本）的集中实验室。处理的主要产物将是DNA、血浆、血清和淋巴细胞。其他生物标本类型，如尿液，脚趾甲，头发样本将纳入未来的设施扩建; 2）提供有效的访问和联络与北卡罗来纳州DNA测序和高重复基因分型核心设施的大学。基因分型设施处理从小规模的试点研究和转化项目到更大规模的基于人群的流行病学研究的广泛需求; 3）为CEHS研究人员提供科学资源，寻求研究设计和进行的建议，包括标本收集和储存方法，以及基因，SNP和单倍型数据库的使用和相关问题。

Description (provided by applicant): The goal of the CEHS Molecular Epidemiology Core is to provide a comprehensive, user friendly, and efficient Core facility that supports CEHS epidemiologic and other studies that require biospecimen (blood, buccal swabs, etc.) processing and high-throughput genotyping. These CEHS services are essential to facilitate and enhance research on environmentally related disease. The goals of the Core are: 1) To provide efficient access to and liaison with the University of North Carolina Biospecimens Processing Laboratory, a centralized laboratory for the processing of biospecimens, primarily blood and buccal rinse samples. The primary products of the processing will be DNA, plasma, serum, and lymphocytes. Additional biospecimen types such as urine, toenails, and hair samples will be incorporated into future facility expansion; 2) To provide efficient access to and liaison with the University of North Carolina DNA Sequencing and High Throughput Genotyping Core Facility. The genotyping facility handles a wide range of needs from smaller scale pilot studies and translational projects to larger population-based epidemiology studies; 3) To provide a scientific resource for CEHS investigators seeking advice on study design and conduct including specimen collection and storage methods, and use of gene, SNP, and haplotype databases and related issues.