CORE-- Molecular Epidemiology

核心——分子流行病学

• 批准号: 7596360
• 负责人: ROBERT C MILLIKAN
• 金额: $ 26.09万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7596360
• 关键词: Blood; Core Facility; DNA; DNA Sequence; Databases; Disease; Epidemiology, Other; Future; Genes; Genotype; Goals; Hair; Haplotypes; Laboratories; Lymphocyte; Methods; Molecular Epidemiology; North Carolina; Pilot Projects; Plasma; Population; Process; Range; Research; Research Design; Research Personnel; Resources; Sampling; Services; Structure of nail of toe; Swab; Universities; Urine; base; epidemiology study; sample collection; user-friendly

Description (provided by applicant): The goal of the CEHS Molecular Epidemiology Core is to provide a comprehensive, user friendly, and efficient Core facility that supports CEHS epidemiologic and other studies that require biospecimen (blood, buccal swabs, etc.) processing and high-throughput genotyping. These CEHS services are essential to facilitate and enhance research on environmentally related disease. The goals of the Core are: 1) To provide efficient access to and liaison with the University of North Carolina Biospecimens Processing Laboratory, a centralized laboratory for the processing of biospecimens, primarily blood and buccal rinse samples. The primary products of the processing will be DNA, plasma, serum, and lymphocytes. Additional biospecimen types such as urine, toenails, and hair samples will be incorporated into future facility expansion; 2) To provide efficient access to and liaison with the University of North Carolina DNA Sequencing and High Throughput Genotyping Core Facility. The genotyping facility handles a wide range of needs from smaller scale pilot studies and translational projects to larger population-based epidemiology studies; 3) To provide a scientific resource for CEHS investigators seeking advice on study design and conduct including specimen collection and storage methods, and use of gene, SNP, and haplotype databases and related issues.

描述（由申请人提供）：CEHS 分子流行病学核心的目标是提供全面、用户友好且高效的核心设施，支持 CEHS 流行病学和其他需要生物样本（血液、口腔拭子等）处理和高通量基因分型的研究。这些 CEHS 服务对于促进和加强环境相关疾病的研究至关重要。核心的目标是： 1) 提供与北卡罗来纳大学生物样本处理实验室的高效访问和联络，该实验室是处理生物样本（主要是血液和口腔冲洗样本）的集中实验室。加工的主要产品是 DNA、血浆、血清和淋巴细胞。其他生物样本类型，如尿液、脚趾甲和头发样本，将纳入未来的设施扩建； 2) 提供与北卡罗来纳大学 DNA 测序和高通量基因分型核心设施的有效访问和联络。基因分型设施可满足从小规模试点研究和转化项目到更大规模的基于人群的流行病学研究的广泛需求； 3) 为CEHS研究人员提供科学资源，以寻求研究设计和实施方面的建议，包括样本收集和储存方法，以及基因、SNP和单倍型数据库的使用以及相关问题。