NEUROECONOMICS OF AGE RELATED CHANGES IN COGNITIVE CONTROL

描述（由申请人提供）：本研究旨在探讨老年人经济决策行为背后的神经和心理机制。经济决策是日常生活的重要组成部分，可能与老年人特别相关（例如，储蓄与支出决策，退休计划，医疗保健选择和药物依从性）。衰老认知神经科学的基础研究表明，老年人控制基于内部目标的思想和行动的能力下降，这可能源于与年龄相关的前额叶外侧皮层和中脑多巴胺系统功能的变化。然而目前，对于这些与年龄增长相关的认知和神经变化是否以及如何影响与经济相关的行为，几乎一无所知。

DESCRIPTION (provided by applicant): This proposal explores the neural and psychological mechanisms that underlie economic decision-making behavior in older adults. Economic decisions are a critical component of everyday life, and may have special relevance for older adults (e.g., saving vs. spending decisions, retirement planning, health care choices, and medication compliance). Basic research in the cognitive neuroscience of aging has suggested that older adults show declines in the ability to control thoughts and actions based on internal goals, and that this may stem from age-related changes in the function of the lateral prefrontal cortex and mid-brain dopamine system. Yet currently, almost nothing is known about whether and how these cognitive and neural changes associated with advancing age impact economic-related behaviors. The current proposal provides a highly novel perspective on this issue, by leveraging and integrating theoretical developments in three areas: a) the cognitive neuroscience of aging; c) neural mechanisms of cognitive control; and c) behavioral economics research. Through the use of novel experimental paradigms and state-of-the-art neuroimaging methods, the proposed studies will systematically examine core components of economic decision-making that may be particularly impacted by age-related changes in cognitive control, including risk-taking and uncertainty, inter- temporal choice, exploration, affective framing effects, and individual difference influences. The findings of these studies promise to provide critical new data regarding economic choice behavior in older adults, and the relationship of such behavior to age-related changes in the neural substrates of cognitive control. This project has high relevance for public health by providing critical information regarding how older adults make economic decisions (e.g., saving vs. spending money) in terms of age-related changes in brain function. An improved understanding of the brain basis of age-related changes in economic decision-making will be critical for determining why and how older adults might be impaired in some decision-related behaviors but not others, and in developing appropriate corrective interventions to address such impairments.