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Nanogold-Enhanced Radiosurgery for Malignant Brain Tumors

纳米金增强放射外科治疗恶性脑肿瘤

基本信息

批准号：
7480724
负责人：
James F Hainfeld
金额：
$ 17.14万
依托单位：
NANOPROBES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7480724
关键词：
Angiotensin II Animal Testing Animals Biodistribution Biological Assay Blood Brain Neoplasms Breast Carcinoma Caliber Canis familiaris Carcinoma Clinical Trials Condition Diffusion Dose Drug or chemical Tissue Distribution Effectiveness Female Glioma Gold Human Hybrids Image Immunotherapy Implant Infusion procedures Left Malignant - descriptor Malignant Glioma Malignant Neoplasms Malignant neoplasm of brain Measures Mediating Metals Modeling Mus Normal tissue morphology Pharmaceutical Preparations Positioning Attribute Procedures Public Health Radiosurgery Rattus Recurrence Roentgen Rays Safety Testing Therapeutic Thigh structure Transgenic Organisms Transplantation Tumor Burden Tumor-Associated Vasculature Weight brain tissue day experience follow-up image guided therapy improved intravenous administration irradiation nanoGold nanoparticle outcome forecast photoactivation success treatment planning tumor uptake v-src Oncogenes

项目摘要

DESCRIPTION (provided by applicant): This proposal builds on the unprecedented success achieved by our earlier studies in safely ablating malignant EMT-6 carcinomas in the thighs of mice by using photoactivation radiosurgery mediated by gold nanoparticles (so-called metal-enhanced radiosurgery [MERS]). MERS will be tested for its safety and efficacy in palliating imminently lethal brain tumors [transgenic v-src malignant gliomas] in mice. As the latter is a neuropathologically documented murine model of human malignant gliomas, it is expected that the proposed study will quickly and economically test the postulate that MERS shows promise to contribute to the palliation of some recurrent human gliomas by greatly decreasing the brain tumor burden, thereby enhancing the effectiveness of adjunct drugs and immunotherapies. Tested positive in mice, positive follow-up tests in rats bearing malignant gliomas and satisfactory normal-tissue tolerance tests in fewer large animals (e.g., dogs) would then enable MERS to be brought to clinical trials. PUBLIC HEALTH RELEVANCE: Malignant brain tumors have poor prognoses and new treatments are needed. Here we present a new treatment using gold nanoparticles that enables image guidance of focused irradiation and even magnification of the dose to malignant brain tumors which, if successful, could significantly improve survival.

描述（由申请人提供）：该提案建立在我们早期研究通过使用金纳米粒子介导的光活化放射外科（所谓的金属增强放射外科[MERS]）安全消融小鼠大腿中的恶性EMT-6癌所取得的前所未有的成功的基础上。MERS将在小鼠中测试其缓解即刻致死性脑肿瘤[转基因v-src恶性胶质瘤]的安全性和有效性。由于后者是一种神经病理学记录的人类恶性神经胶质瘤小鼠模型，因此预计拟议的研究将快速经济地测试以下假设，即MERS有望通过大大降低脑肿瘤负荷来缓解一些复发性人类神经胶质瘤，从而增强辅助药物和免疫疗法的有效性。在小鼠中检测为阳性，在患有恶性神经胶质瘤的大鼠中进行了阳性随访试验，在少数大型动物中进行了令人满意的正常组织耐受性试验（例如，狗）将使MERS进入临床试验。公共卫生相关性：恶性脑肿瘤的预后差，需要新的治疗方法。在这里，我们提出了一种新的治疗方法，使用金纳米粒子，使图像引导的集中照射，甚至放大剂量的恶性脑肿瘤，如果成功，可以显着提高生存。