AN EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
绒毛膜羊膜炎和早产的实验模型
基本信息
- 批准号:7561875
- 负责人:
- 金额:$ 7.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-05-01 至 2008-04-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingBacteriaCessation of lifeComputer Retrieval of Information on Scientific Projects DatabaseCongenital AbnormalityDiscipline of obstetricsExperimental ModelsFundingGrantHourInfectionInfection of amniotic sac and membranesInstitutionInterventionLinkMacaca mulattaMatrix MetalloproteinasesMolecularNeonatalPatient currently pregnantPremature BirthPremature LaborPrematurity of fetusProductionProstaglandinsResearchResearch PersonnelResourcesSourceStreptococcus Group BTestingUnited States National Institutes of HealthUterine Contractioncytokineneonate
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Prematurity and its consequences remain the most important problem in obstetrics. The 12% of neonates born prematurely account for 80% of neonatal deaths not attributable to congenital malformations. Intrauterine infections are an important, and potentially preventable, cause of preterm delivery. The long-term objectives of this research are: a) to elucidate the pathophysiologic mechanisms of infection-induced preterm labor; b) to establish the cellular and molecular links among intrauterine infection and preterm labor; and c) to test the efficacy of rational interventional strategies for preterm labor in the setting of infection. We developed the first experimental model in pregnant rhesus monkeys in which intrauterine infection is established by the intraamniotic inoculation of known concentrations of Group B streptococcus (GBS) bacteria. Following inoculation, there is sequential production of the proinflammmatory cytokines, prostaglandins, and matrix metalloproteinases (MMPs). This is then followed in all cases by uterine contraction, labor and delivery, usually within 72 hours.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
早产及其后果仍然是产科最重要的问题。 12%的早产新生儿占非先天性畸形新生儿死亡的80%。 宫内感染是早产的一个重要原因,也是可以预防的。 本研究的长期目标是:a)阐明感染性早产的病理生理机制; B)建立宫内感染和早产之间的细胞和分子联系; c)测试感染背景下早产的合理干预策略的有效性。 我们在妊娠恒河猴中开发了第一个实验模型,其中通过羊膜内接种已知浓度的B族链球菌(GBS)细菌建立宫内感染。 接种后,相继产生促炎性细胞因子、胰高血糖素和基质金属蛋白酶(MMP)。 然后,在所有情况下,子宫收缩,分娩和分娩,通常在72小时内。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MICHAEL G GRAVETT其他文献
MICHAEL G GRAVETT的其他文献
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{{ truncateString('MICHAEL G GRAVETT', 18)}}的其他基金
AN EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
绒毛膜羊膜炎和早产的实验模型
- 批准号:
7348889 - 财政年份:2006
- 资助金额:
$ 7.59万 - 项目类别:
AN EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
绒毛膜羊膜炎和早产的实验模型
- 批准号:
7165203 - 财政年份:2005
- 资助金额:
$ 7.59万 - 项目类别:
AN EXPERIMENTAL MODEL FOR CHORIOAMNIONITIS AND PREMATURITY
绒毛膜羊膜炎和早产的实验模型
- 批准号:
6970640 - 财政年份:2004
- 资助金额:
$ 7.59万 - 项目类别:
INTERLEUKIN 10 INHIBITS INTERLEUKIN 1? INDUCED PRETERM LABOR IN RHESUS MONKEYS
白细胞介素 10 抑制白细胞介素 1?
- 批准号:
6592311 - 财政年份:2002
- 资助金额:
$ 7.59万 - 项目类别:
INTERLEUKIN 10 INHIBITS INTERLEUKIN 1? INDUCED PRETERM LABOR IN RHESUS MONKEYS
白细胞介素 10 抑制白细胞介素 1?
- 批准号:
6453687 - 财政年份:2001
- 资助金额:
$ 7.59万 - 项目类别:
INTERLEUKIN 10 INHIBITS INTERLEUKIN 1? INDUCED PRETERM LABOR IN RHESUS MONKEYS
白细胞介素 10 抑制白细胞介素 1?
- 批准号:
6116159 - 财政年份:1999
- 资助金额:
$ 7.59万 - 项目类别:
EXPERIMENTAL MODEL FOR CHORIODECIDUAL INFECTION & PRETERM LABOR IN MACAQUES
脉络膜蜕膜感染的实验模型
- 批准号:
6277391 - 财政年份:1998
- 资助金额:
$ 7.59万 - 项目类别:
INTERLEUKIN 10 INHIBITS PRETERM UTERINE CONTRACTIONS INDUCED BY INTERLEUKIN 1
白细胞介素 10 抑制白细胞介素 1 引起的早产子宫收缩
- 批准号:
6277398 - 财政年份:1998
- 资助金额:
$ 7.59万 - 项目类别:
INDUCTION OF HEAT SHOCK PROTEIN BY INTERLEUKIN 1 INTRAAMNIOTIC INFUSION
羊膜腔内输注白细胞介素 1 诱导热休克蛋白
- 批准号:
6277397 - 财政年份:1998
- 资助金额:
$ 7.59万 - 项目类别:
Experimental Model for Chorioamnionitis and Prematurity
绒毛膜羊膜炎和早产的实验模型
- 批准号:
6631996 - 财政年份:1997
- 资助金额:
$ 7.59万 - 项目类别:
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