Support of Yerkes National Primate Research Center

耶基斯国家灵长类研究中心的支持

• 批准号: 10190517
• 负责人: JONATHAN S LEWIN
• 金额: $ 47.62万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-16 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10190517
• 关键词: Animal Housing; Basic Science; Behavioral; Behavioral Research; Biocompatible Materials; Biology; Biomedical Research; Breeding; Collaborations; Communities; Consultations; Development; Discipline; Ensure; Environment; Faculty; Funding; Genetic; Goals; Grant; Guidelines; Health; Housing; Human; Immunology; Infrastructure; International; Knowledge; Laboratory Research; Mental disorders; Microbiology; Mission; Neuropharmacology; Neurosciences; Pathology; Personal Satisfaction; Postdoctoral Fellow; Primates; Process; Publications; Reporting; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Role; Scientist; Services; Social Behavior; Strategic Planning; Translational Research; Transplantation; United States National Institutes of Health; Universities; Visit; animal facility; animal resource; base; cognitive neuroscience; data resource; graduate student; improved; innovation; laboratory facility; medical specialties; member; multidisciplinary; nervous system disorder; nonhuman primate; programs; training opportunity; undergraduate student

OVERALL – SUMMARY/ABSTRACT This application seeks five years of continued support for the P51 Base Grant (OD 011132) for the Yerkes National Primate Research Center of Emory University. The overarching goals of Yerkes are to conduct a research program focused on scientific problems relevant to human health and the NIH mission by providing resource infrastructure and expertise in appropriate scientific and veterinary specialties and to ensure the Center's ability to serve as a resource to Core Scientists, as well as to scientists regionally, nationally and internationally. During the current reporting period (5/1/2011 to present), the Yerkes Center has recorded remarkable progress, as evidenced by numerous (>790) publications, construction of new animal facilities, including a state-of-the-art transplantation and ABSL3 facility, and progressive expansion of its research funding base, even in the era of an extremely competitive NIH funding environment. In addition, the Yerkes Primate Center has maintained outstanding core research programs and provided resources and services to a broad multidisciplinary network of affiliate and collaborative investigators throughout the region and nation. These research programs, which involve the use of a variety of nonhuman primate species, are directed primarily toward four major research disciplines, representing the research divisions within the Yerkes Center: 1) Microbiology and Immunology; 2) Developmental and Cognitive Neuroscience, 3) Neuropharmacology and Neurologic Diseases and 4) Behavioral Neuroscience and Psychiatric Disorders. Also, through the Divisions of Animal Resources and Pathology, Yerkes provides support for outside investigators conducting research at the Yerkes Center, consistent with our ORIP-mandated role as a regional and national resource. Specific aims for the upcoming period of support include: 1) To carry out basic and translational research using nonhuman primates to expand knowledge, develop improved treatments, and advance cures that will benefit humanity; 2) To provide regional and national resources for data, consultative expertise, biologic materials, and specialized facilities useful in supporting nonhuman primate research; 3) To study basic nonhuman primate biology and improve nonhuman primate breeding, husbandry and genetic characterization to better serve the biomedical research community; and 4) To provide research and training opportunities involving nonhuman primates to graduate and undergraduate students, postdoctoral fellows, visiting scientists and faculty members. The pursuit of these aims will enhance the Center's ability to serve as an enabling resource to Core and Affiliate Scientists for the conduct of nonhuman primate research, all for the ultimate goal of advancing human health.

总体——总结/摘要 本申请寻求为 Yerkes 的 P51 基本补助金 (OD 011132) 提供五年持续支持 埃默里大学国家灵长类动物研究中心。 Yerkes 的总体目标是开展 研究计划侧重于与人类健康和 NIH 使命相关的科学问题，通过提供 适当科学和兽医专业的资源基础设施和专业知识，并确保 中心有能力为核心科学家以及地区、国家和地区的科学家提供资源 国际上。在本报告期内（2011 年 5 月 1 日至今），耶基斯中心记录了 大量（>790）出版物、新动物设施的建设、 包括最先进的移植和 ABSL3 设施，并逐步扩展其研究 即使在 NIH 资金环境竞争极其激烈的时代，资金基础也是如此。此外，耶克斯 灵长类动物中心保持着出色的核心研究项目，并为 由整个地区和国家的附属和合作研究人员组成的广泛的多学科网络。 这些研究计划涉及使用各种非人类灵长类动物， 主要面向四个主要研究学科，代表耶克斯中心内的研究部门： 1）微生物学和免疫学； 2) 发育和认知神经科学，3) 神经药理学和 神经系统疾病和 4) 行为神经科学和精神疾病。此外，通过各部门 动物资源和病理学，Yerkes 为外部研究人员在该中心进行研究提供支持 Yerkes 中心，符合我们 ORIP 规定的区域和国家资源角色。具体目标为 未来一段时间的支持包括： 1）利用非人类开展基础和转化研究 灵长类动物扩大知识，开发改进的治疗方法，并推进造福人类的治疗方法； 2） 提供区域和国家数据、咨询专业知识、生物材料和专业资源 可用于支持非人类灵长类动物研究的设施； 3) 研究非人类灵长类动物的基础生物学 改善非人类灵长类动物的育种、饲养和遗传特征，更好地服务于生物医学 研究团体； 4) 提供涉及非人类灵长类动物的研究和培训机会 研究生和本科生、博士后研究员、访问科学家和教职人员。这 实现这些目标将增强该中心作为核心和附属机构的支持资源的能力 科学家对于非人类灵长类动物的研究，一切都是为了促进人类健康的最终目标。