SERUM BIOMARKERS OF ALCOHOL SELF ADMINISTRATION IN NON-HUMAN PRIMATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 也许治疗酗酒和酗酒的最大障碍是缺乏可用于诊断和监测过度饮酒的工具。由于许多原因(例如，与酗酒有关的社会耻辱，以及坦率酗酒的潜在法律/社会后果)，自我报告的使用虽然具有信息性，但众所周知是不一致的。事实上，患者拒绝饮酒是有动机的。这导致了寻找酗酒的生化标记物。已经提出了几种酒精中毒的生化标志物，但这些检测的准确性和敏感性存在局限性。这些生物标志物包括：平均红细胞体积、碳水化合物缺乏的转铁蛋白、γ-谷氨酰转移酶、天冬氨酸转氨酶和乙基葡萄糖醛酸苷。本研究建议将酒精自我给药的非人类灵长类动物模型的力量与新的高通量蛋白质组学技术相结合，以识别额外的过度饮酒的诊断血浆蛋白生物标志物标志。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Perhaps the most significant barrier in the treatment of alcohol abuse and alcoholism is the paucity of tools available for diagnosing and monitoring excessive alcohol consumption. For many reasons, (e.g., social stigma associated with alcohol abuse, and the potential legal/social ramifications of frank alcoholism), self-reported use, though informative, is known to be inconsistent. Indeed, there is a motivation for patients to deny drinking. This has led to the search for biochemical markers of alcohol abuse. Several biochemical markers of alcoholism have been proposed, but there are limitations to the accuracy and sensitivity of these assays. These biomarkers include: mean corpuscular volume, carbohydrate-deficient transferrin, gamma-glutamyl transferase, aspartate aminotransferase, and ethylglucuronide. The present study proposes to combine the power of a non-human primate model of alcohol self-administration with new, high-throughput proteomic techniques to identify additional diagnostic plasma protein biomarker signatures of excessive alcohol consumption.