MONKEY ALCOHOL TISSUE RESEARCH RESOURCE (MATRR)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 偶尔或长期过量饮酒，会与影响大脑和行为的内科疾病以及其他器官损伤并存。关于大量饮酒的风险和后果，包括器官损害的机制，人们所知的很大一部分来自啮齿动物研究或回溯性的人类描述。猴子酒精组织研究资源(MATRR)是一个独特的死后组织库，旨在确保长期饮酒的动物的组织以及与它们相关的饮酒和遗传信息可供更广泛的酒精研究社区使用，以确保减少研究中使用的动物数量。该组织来自ONPRC(恒河猴和食蟹猴)和维克森林(马鞭草)三种猴子的酒精自我给药标准方案。这一资源将为假设检验提供新的数据，涉及饮酒的风险和后果，并有助于双向弥合啮齿动物和人类研究之间的差距。MATRR的基础是非人灵长类动物，特别是猴子，表现出长期(12-30个月)过量饮酒(3.0克/公斤或12杯当量/天)，并伴随着内分泌、肝脏和中枢神经系统(CNS)过程的病理变化。这些纵向设计跨越了饮酒的“阶段”，从天真的乙醇到早期接触酒精再到慢性滥用。对纸巾的需求和质量已经很高，这反映在请求和出版物的数量上。然而，这一资源需要进一步开发，才能发挥其作为酒精中毒研究前沿翻译工具的潜力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Excessive alcohol ingestion, occasionally or chronically, is co-morbid with medical disorders affecting the brain and behavior as well as other organ damage. Much of what is known about risk for and the consequence of heavy alcohol consumption, including mechanisms of organ damage, is derived from rodent studies or retrospective human accounts. The Monkey Alcohol Tissue Research Resource (MATRR) is a unique post-mortem tissue bank to ensure tissue from animals chronically drinking alcohol, as well as their related drinking and genetic information, is available to the wider alcohol research community insuring reduced numbers of animals used in research. The tissue is derived from a standard protocol of ethanol self-administration in three species of monkeys housed at ONPRC (rhesus and cynomolgus) and Wake Forest (vervet). This resource will provide novel data for hypothesis testing relating the risk for and consequences of alcohol consumption and serve to bi-directionally bridge the gap between rodent and human studies. The basis of the MATRR is that non human primates, specifically monkeys, show a range of drinking excessive amounts of alcohol (3.0 g/kg or a 12 drink equivalent/day) over long periods of time (12-30 months) with concomitant pathological changes in endocrine, hepatic and central nervous system (CNS) processes. These longitudinal designs span "stages of drinking" from ethanol-naive to early alcohol exposure to chronic abuse. The demand for, and the quality of, the tissues are already high as reflected in the number of requests and publications. Nevertheless, this resource needs further development in order to fulfill its potential as a cutting edge translational tool in alcoholism research.