STRESS AND ETHANOL SELF-ADMINISTRATION IN MONKEYS
猴子的压力和乙醇自我管理
基本信息
- 批准号:8357781
- 负责人:
- 金额:$ 5.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-05-01 至 2012-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdrenal GlandsAlcohol abuseAlcohol consumptionBehaviorChronicCorticotropinEndocrineEthanolFundingGenesGenetic PolymorphismGrantHormonesHydrocortisoneHypothalamic structureIndividualIndividual DifferencesMeasurableMonkeysNational Center for Research ResourcesNatureOutputPhenotypePituitary GlandPopulationPopulation DistributionsPrimatesPrincipal InvestigatorProceduresResearchResearch InfrastructureResourcesRiskRoleSelf AdministrationSelf-AdministeredSourceStressStressful EventUnited States National Institutes of Healthcostendophenotypehypothalamic-pituitary-adrenal axisresponse
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Stress is believed to be an etiological factor in the abuse of ethanol. However, the role of stress in the risk for excessive ethanol consumption is difficult to untangle from the stress derived from excessively drinking alcohol. A starting point is to operationally define stress as activation of the hypothalamic-pituitary-adrenal (HPA) axis through measurable changes in circulating levels of the hormones adrenocorticotropin (ACTH) from the pituitary and cortisol from the adrenals. Monkeys show clear individual differences in endocrine response of the HPA axis to stressful events and also clear individual differences in the amount of ethanol they choose to self-administer. To address the causal interaction of stress and excessive ethanol interaction, we proposed to characterize individual differences in HPA response to stress prior to, during and following chronic ethanol self administration. Further, the very nature of endocrine response to stress brings into focus the concept of neurocircuitries underlying information flow, integration and functional output. Viewing the HPA response as an intermediate determinant of behavior guides a translational endeavor into the realm of intermediate phenotypes or "endophenotypes". To address the predictive validity of an HPA response as an endophenotype underlying the risk of excessive ethanol self-administration, we have screened a large population of monkeys for specific HPA responses. Individuals on the extreme ends of the population distribution of the potential endophenotype were characterized in the ethanol self-administration procedure. Gene polymorphisms to identify those associated with an HPA response endophenotype are underway.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
子项目的主要研究者可能是由其他来源提供的,
包括其它NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
压力被认为是滥用乙醇的一个病因。然而,压力在过度饮酒风险中的作用很难从过度饮酒的压力中解脱出来。一个出发点是操作上定义的压力激活下丘脑-垂体-肾上腺(HPA)轴通过可测量的变化,促肾上腺皮质激素(ACTH)从垂体和皮质醇从肾上腺的循环水平。猴子在HPA轴对压力事件的内分泌反应中表现出明显的个体差异,并且在它们选择自我管理的乙醇量上也表现出明显的个体差异。为了解决压力和过量乙醇相互作用的因果关系,我们提出了表征HPA应激反应的个体差异之前,期间和之后的慢性乙醇自我管理。此外,内分泌对压力的反应的本质使信息流、整合和功能输出的神经回路概念成为焦点。将HPA反应视为行为的中间决定因素,引导了转化奋进进入中间表型或“内表型”的领域。为了解决HPA反应作为过度乙醇自我给药风险的内在表型的预测有效性,我们筛选了大量猴的特异性HPA反应。在乙醇自我给药程序中,对潜在内在表型的群体分布的极端个体进行了表征。基因多态性,以确定那些与HPA反应内表型正在进行中。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KATHLEEN A GRANT其他文献
KATHLEEN A GRANT的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KATHLEEN A GRANT', 18)}}的其他基金
Symposium on Data Integration from the Monkey Model of Alcohol Drinking
猴子饮酒模型数据整合研讨会
- 批准号:
8837787 - 财政年份:2014
- 资助金额:
$ 5.82万 - 项目类别:
MONKEY ALCOHOL TISSUE RESEARCH RESOURCE (MATRR)
猴子酒精组织研究资源 (MATRR)
- 批准号:
8357856 - 财政年份:2011
- 资助金额:
$ 5.82万 - 项目类别:
Monkey Alcohol Tissue Research Resource (MATRR)
猴子酒精组织研究资源 (MATRR)
- 批准号:
8144913 - 财政年份:2010
- 资助金额:
$ 5.82万 - 项目类别:
Monkey Alcohol Tissue Research Resource (MATRR)
猴子酒精组织研究资源 (MATRR)
- 批准号:
8308542 - 财政年份:2010
- 资助金额:
$ 5.82万 - 项目类别:
Monkey Alcohol Tissue Research Resource (MATRR)
猴子酒精组织研究资源 (MATRR)
- 批准号:
8702033 - 财政年份:2010
- 资助金额:
$ 5.82万 - 项目类别:
Monkey Alcohol Tissue Research Resource (MATRR)
猴子酒精组织研究资源 (MATRR)
- 批准号:
8508751 - 财政年份:2010
- 资助金额:
$ 5.82万 - 项目类别:
相似海外基金
Role of hypothalamic MC4R in glucose homeostasis via a novel neuroendocrine circuit involving the kidneys and adrenal glands
下丘脑 MC4R 通过涉及肾脏和肾上腺的新型神经内分泌回路在葡萄糖稳态中的作用
- 批准号:
10454300 - 财政年份:2021
- 资助金额:
$ 5.82万 - 项目类别:
Role of hypothalamic MC4R in glucose homeostasis via a novel neuroendocrine circuit involving the kidneys and adrenal glands
下丘脑 MC4R 通过涉及肾脏和肾上腺的新型神经内分泌回路在葡萄糖稳态中的作用
- 批准号:
10666539 - 财政年份:2021
- 资助金额:
$ 5.82万 - 项目类别:
Role of hypothalamic MC4R in glucose homeostasis via a novel neuroendocrine circuit involving the kidneys and adrenal glands
下丘脑 MC4R 通过涉及肾脏和肾上腺的新型神经内分泌回路在葡萄糖稳态中的作用
- 批准号:
10296199 - 财政年份:2021
- 资助金额:
$ 5.82万 - 项目类别:
Role of hypothalamic MC4R in glucose homeostasis via a novel neuroendocrine circuit involving the kidneys and adrenal glands
下丘脑 MC4R 通过涉及肾脏和肾上腺的新型神经内分泌回路在葡萄糖稳态中的作用
- 批准号:
10854123 - 财政年份:2021
- 资助金额:
$ 5.82万 - 项目类别:
Interaction of adrenal glands and liver in canine hepatocellular carcinoma
犬肝细胞癌中肾上腺和肝脏的相互作用
- 批准号:
20H03139 - 财政年份:2020
- 资助金额:
$ 5.82万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Role of dendritic cells in adrenal glands of healthy and arthritic rats
树突状细胞在健康和关节炎大鼠肾上腺中的作用
- 批准号:
235438724 - 财政年份:2013
- 资助金额:
$ 5.82万 - 项目类别:
Research Grants
Role of neural cell adhesion molecules in structural and functional remodeling of fetal adrenal glands
神经细胞粘附分子在胎儿肾上腺结构和功能重塑中的作用
- 批准号:
20591305 - 财政年份:2008
- 资助金额:
$ 5.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Search for the novel etiology in disorders of sex development (DSD) caused by abnormalities of adrenal glands and gonads.
寻找由肾上腺和性腺异常引起的性发育障碍 (DSD) 的新病因。
- 批准号:
16086202 - 财政年份:2004
- 资助金额:
$ 5.82万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Effects of endocrine disrupters on function of thyroid gland, adrenal glands and gonads
内分泌干扰物对甲状腺、肾上腺和性腺功能的影响
- 批准号:
11839003 - 财政年份:1999
- 资助金额:
$ 5.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Roles of Thyroid and Adrenal glands in the regulation of hypothalamo-hypophysial-ovarian axis in the rat.
甲状腺和肾上腺在大鼠下丘脑-垂体-卵巢轴调节中的作用。
- 批准号:
06660375 - 财政年份:1994
- 资助金额:
$ 5.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)