BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION

酒精神经适应的行为基因组学

• 批准号: 8173268
• 负责人: KATHLEEN A GRANT
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173268
• 关键词: Adult; Alcohols; Ataxia; CCL18 gene; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Dexamethasone; Dose; Endocrine; Ethanol; Funding; Genes; Goals; Grant; Head; Heritability; Hormonal; Human; Institution; Macaca mulatta; Measures; Monkeys; Motor; Research; Research Personnel; Research Project Grants; Resources; Self Administration; Source; United States National Institutes of Health; Youth; alcohol effect; alcohol response; alcohol use disorder; behavioral genomics; design; human subject; neuroadaptation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Initial sensitivity and its relation to the development of alcohol use disorders in human subject studies has most often been measured with subjective responses, motor in coordination, or hormonal response [Farren and Tipton, 1999; Heath, 1999; Schuckit, 2001]. With these measures, a low response to alcohol in humans has been estimated to have a heritability between 0.4 and 06. The research project headed by Dr. Judy Cameron is designed to determine heritability of alcohol-induced ataxia following a single high dose (2.0 g/kg) of ethanol in ethanol na¿ve monkeys This study is an ongoing linkage study in young rhesus monkeys designed to identify genes underlying sensitivity to the intoxicating effects of ethanol and has been funded through the PARC since 2004. Our goal is to determine if initial sensitivity to the intoxicating effects of ethanol can predict the extent of alcohol self-administration after the monkey has reached adulthood. Currently, these monkeys are in their 8th month of ethanol self-administration. In addition, basal endocrine profiles and changes induced by a low level of dexamethasone suppression have been assessed. Data will be combined with rhesus monkeys that had not been exposed to ethanol during their youth.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在人类研究中，最初的敏感性及其与酒精使用障碍发展的关系通常是通过主观反应、运动协调或激素反应来衡量的(Farren和Tipton，1999；Heath，1999；Schuckit，2001)。有了这些措施，人类对酒精的低反应估计有0.4到06之间的遗传率。由朱迪·卡梅隆博士领导的这项研究项目旨在确定单次高剂量(2.0g/kg)乙醇对猕猴酒精诱导的共济失调的遗传性。这项研究是一项正在进行的针对幼年恒河猴的连锁研究，旨在确定潜在的基因 自2004年以来，该项目一直通过帕洛阿尔托研究中心提供资金。我们的目标是确定最初对酒精的醉人效应的敏感性是否可以预测猴子成年后酒精自我给药的程度。目前，这些猴子正在进行8个月的乙醇自我给药。此外，还评估了基础内分泌情况和低水平地塞米松抑制引起的变化。数据将与年轻时未接触过乙醇的恒河猴相结合。