BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION

酒精神经适应的行为基因组学

• 批准号: 8173268
• 负责人: KATHLEEN A GRANT
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173268
• 关键词: Adult; Alcohols; Ataxia; CCL18 gene; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Dexamethasone; Dose; Endocrine; Ethanol; Funding; Genes; Goals; Grant; Head; Heritability; Hormonal; Human; Institution; Macaca mulatta; Measures; Monkeys; Motor; Research; Research Personnel; Research Project Grants; Resources; Self Administration; Source; United States National Institutes of Health; Youth; alcohol effect; alcohol response; alcohol use disorder; behavioral genomics; design; human subject; neuroadaptation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Initial sensitivity and its relation to the development of alcohol use disorders in human subject studies has most often been measured with subjective responses, motor in coordination, or hormonal response [Farren and Tipton, 1999; Heath, 1999; Schuckit, 2001]. With these measures, a low response to alcohol in humans has been estimated to have a heritability between 0.4 and 06. The research project headed by Dr. Judy Cameron is designed to determine heritability of alcohol-induced ataxia following a single high dose (2.0 g/kg) of ethanol in ethanol na¿ve monkeys This study is an ongoing linkage study in young rhesus monkeys designed to identify genes underlying sensitivity to the intoxicating effects of ethanol and has been funded through the PARC since 2004. Our goal is to determine if initial sensitivity to the intoxicating effects of ethanol can predict the extent of alcohol self-administration after the monkey has reached adulthood. Currently, these monkeys are in their 8th month of ethanol self-administration. In addition, basal endocrine profiles and changes induced by a low level of dexamethasone suppression have been assessed. Data will be combined with rhesus monkeys that had not been exposed to ethanol during their youth.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在人类受试者研究中，初始敏感性及其与酒精使用障碍发展的关系最常通过主观反应、运动协调或激素反应进行测量[Farren and Tipton，1999; Heath，1999; Schuckit，2001]。通过这些措施，人类对酒精的低反应估计具有0.4至0.6之间的遗传性。由Judy卡梅隆博士领导的研究项目旨在确定未经乙醇处理的猴子在单次高剂量（2.0 g/kg）乙醇后酒精诱导的共济失调的遗传性。 自2004年以来，该项目一直通过PARC提供资金。我们的目标是确定是否初始敏感性酒精的致醉作用可以预测酒精自我管理的程度后，猴子已经达到成年。 目前，这些猴子处于乙醇自我给药的第8个月。 此外，还评估了低水平地塞米松抑制诱导的基础内分泌特征和变化。 数据将与未暴露于乙醇的恒河猴在其青年。