BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION

酒精神经适应的行为基因组学

• 批准号: 8173268
• 负责人: KATHLEEN A GRANT
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173268
• 关键词: Adult; Alcohols; Ataxia; CCL18 gene; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Dexamethasone; Dose; Endocrine; Ethanol; Funding; Genes; Goals; Grant; Head; Heritability; Hormonal; Human; Institution; Macaca mulatta; Measures; Monkeys; Motor; Research; Research Personnel; Research Project Grants; Resources; Self Administration; Source; United States National Institutes of Health; Youth; alcohol effect; alcohol response; alcohol use disorder; behavioral genomics; design; human subject; neuroadaptation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Initial sensitivity and its relation to the development of alcohol use disorders in human subject studies has most often been measured with subjective responses, motor in coordination, or hormonal response [Farren and Tipton, 1999; Heath, 1999; Schuckit, 2001]. With these measures, a low response to alcohol in humans has been estimated to have a heritability between 0.4 and 06. The research project headed by Dr. Judy Cameron is designed to determine heritability of alcohol-induced ataxia following a single high dose (2.0 g/kg) of ethanol in ethanol na¿ve monkeys This study is an ongoing linkage study in young rhesus monkeys designed to identify genes underlying sensitivity to the intoxicating effects of ethanol and has been funded through the PARC since 2004. Our goal is to determine if initial sensitivity to the intoxicating effects of ethanol can predict the extent of alcohol self-administration after the monkey has reached adulthood. Currently, these monkeys are in their 8th month of ethanol self-administration. In addition, basal endocrine profiles and changes induced by a low level of dexamethasone suppression have been assessed. Data will be combined with rhesus monkeys that had not been exposed to ethanol during their youth.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在人类受试者研究中，最初的敏感性及其与酒精使用障碍发展的关系最常通过主观反应、运动协调性或激素反应来测量[Farren 和 Tipton，1999；希思，1999；舒基特，2001]。通过这些措施，人类对酒精的低反应估计具有 0.4 至 06 之间的遗传力。由 Judy Cameron 博士领导的研究项目旨在确定在未接触过乙醇的猴子中单次高剂量（2.0 g/kg）乙醇后酒精引起的共济失调的遗传力。这项研究是一项在年轻恒河猴中正在进行的连锁研究，旨在识别潜在的基因 猴子对乙醇中毒作用的敏感性，自 2004 年以来一直通过 PARC 资助。我们的目标是确定对乙醇中毒作用的初始敏感性是否可以预测猴子成年后自我饮酒的程度。 目前，这些猴子正处于自我注射乙醇的第八个月。 此外，还评估了基础内分泌谱和低水平地塞米松抑制引起的变化。 数据将与年轻时未接触过乙醇的恒河猴相结合。