BEHAVIORAL GENOMICS OF ALCOHOL NEUROADAPTATION

酒精神经适应的行为基因组学

• 批准号: 8173268
• 负责人: KATHLEEN A GRANT
• 金额: $ 7.61万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173268
• 关键词: Adult; Alcohols; Ataxia; CCL18 gene; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Dexamethasone; Dose; Endocrine; Ethanol; Funding; Genes; Goals; Grant; Head; Heritability; Hormonal; Human; Institution; Macaca mulatta; Measures; Monkeys; Motor; Research; Research Personnel; Research Project Grants; Resources; Self Administration; Source; United States National Institutes of Health; Youth; alcohol effect; alcohol response; alcohol use disorder; behavioral genomics; design; human subject; neuroadaptation; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Initial sensitivity and its relation to the development of alcohol use disorders in human subject studies has most often been measured with subjective responses, motor in coordination, or hormonal response [Farren and Tipton, 1999; Heath, 1999; Schuckit, 2001]. With these measures, a low response to alcohol in humans has been estimated to have a heritability between 0.4 and 06. The research project headed by Dr. Judy Cameron is designed to determine heritability of alcohol-induced ataxia following a single high dose (2.0 g/kg) of ethanol in ethanol na¿ve monkeys This study is an ongoing linkage study in young rhesus monkeys designed to identify genes underlying sensitivity to the intoxicating effects of ethanol and has been funded through the PARC since 2004. Our goal is to determine if initial sensitivity to the intoxicating effects of ethanol can predict the extent of alcohol self-administration after the monkey has reached adulthood. Currently, these monkeys are in their 8th month of ethanol self-administration. In addition, basal endocrine profiles and changes induced by a low level of dexamethasone suppression have been assessed. Data will be combined with rhesus monkeys that had not been exposed to ethanol during their youth.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 最初的敏感性及其与人类学科研究中酒精使用障碍发展的关系最常通过受试者反应，协调性运动或荷尔蒙反应来衡量[Farren and Tipton，1999;希思，1999年； Schuckit，2001年]。有了这些措施，估计人类对酒精的反应低于0.4至06之间。朱迪·卡梅伦（Judy Cameron）博士领导的研究项目旨在确定在乙醇naquys中，乙醇中的乙醇乙醇乙醇的单一高剂量（2.0 g/kg）在这项研究中，这项研究是在这项研究中，这是一项良好的链接研究，这是在乙醇中识别的，这是在乙醇中识别的，这是在乙醇中识别的，这是在进行中的乙醇中，这是一个良好的介绍。 自2004年以来，对乙醇的抗毒性作用的敏感性已通过PARC进行了资金。我们的目标是确定对乙醇的肠毒性作用的初始敏感性是否可以预测猴子成年后酒精自我给药的程度。目前，这些猴子处于乙醇自我管理的第8个月。此外，已经评估了低地塞米松抑制作用引起的基本内分泌谱和变化。数据将与年轻时未暴露于乙醇的恒河猴结合使用。