FOOD-BORNE ANTHRAX THREAT ASSESSMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 炭疽是一种革兰氏阳性孢子形成细菌，感染人类和动物。 当个人接触来自受感染动物的材料或吸入与动物产品相关的孢子时，自然发生人类感染。 感染可以三种形式发生：皮肤、吸入和胃肠道。 如果不及时治疗，任何形式的疾病都可能导致死亡。 这种疾病最致命的形式是吸入性炭疽，表现为喉咙痛、轻度发烧、肌肉疼痛和不适。 死亡率约为50%，即使在使用抗生素的情况下也是如此。 关于胃肠道炭疽的死亡率所知甚少。 该项目的最终目标是描述非人灵长类动物疾病的发病机制，并评估氟喹诺酮治疗在预防致命疾病方面的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anthrax is a gram-positive spore forming bacteria that infects both humans and animals. Natural human infections occur when individuals handle materials from infected animals or inhale spores associated with animal products. Infection can occur in three forms: cutaneous, inhalation and gastrointestinal. If left untreated, all forms of the disease could result in death. The most fatal form of the disease, inhalation anthrax, presents with sore throat, mild fever, muscle aches and malaise. The mortality rate is approximately 50% even with care that includes the use of antibiotics. Much less information is known about the mortality of GI anthrax. The ultimate goal for this project is to characterize pathogenesis of disease in nonhuman primates and to assess effectiveness of fluoroquinolone treatment in protecting against lethal disease.