FOOD-BORNE TULAREMIA THREAT ASSESSMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 革兰氏阴性杆菌是图拉氏菌病的病原菌。天然水库包括小型哺乳动物，如地松鼠、野兔、田鼠、麝鼠、水鼠、兔子和其他啮齿动物。这种疾病从受感染的水库和其他小型脊椎动物通过直接接触或从节肢动物媒介传播给人类。兔热病的表现形式多种多样，包括接种部位的溃疡、咽炎、淋巴结病和肺炎。立即使用适当的抗生素治疗可以减少危及生命的肺炎的可能性。图拉氏丝虫是一种A类药物。据报道，吸入这种药物的感染量只有10种微生物。关于胃肠道热血症的死亡率的信息要少得多。该项目的最终目标是确定非人类灵长类动物疾病的发病机制，并评估氟喹诺酮类药物在预防致命疾病方面的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The gram-negative coccobacillus Francisella tularensis is the causative agent of tularemia. The natural reservoir includes small mammals such as ground squirrels, hares, voles, muskrats, water rats, rabbits and other rodents. This illness is spread to humans from infected reservoirs and other small vertebrates through direct contact or transmission from an arthropod vector. Tularemia is manifested in various ways including ulcers at the site of inoculation, pharyngitis, lymphadenopathy, and pneumonia. Immediate treatment with appropriate antibiotics can reduce the possibility of life-threatening pneumonia. F. tularensis is a category A agent. The infectious dose for this agent by inhalation is reported to be as few as 10 organisms. Much less information is known about the mortality of GI tularemia. The ultimate goal for this project is to characterize pathogenesis of disease in nonhuman primates and to assess effectiveness of fluoroquinolone treatment in protecting against lethal disease.