FOOD-BORNE TULAREMIA THREAT ASSESSMENT

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 革兰氏阴性球杆菌土拉弗朗西斯菌是兔热病的病原体。 天然宿主包括小型哺乳动物，如地松鼠、野兔、田鼠、麝香鼠、水鼠、兔子和其他啮齿动物。 这种疾病通过直接接触或节肢动物媒介传播，从受感染的宿主和其他小型脊椎动物传播给人类。 兔热病有多种表现，包括接种部位溃疡、咽炎、淋巴结肿大和肺炎。 立即使用适当的抗生素治疗可以减少危及生命的肺炎的可能性。 F. tularensis 是 A 类病原体。 据报道，这种病原体的吸入感染剂量仅为 10 种生物体。关于胃肠道兔热病死亡率的信息知之甚少。 该项目的最终目标是确定非人类灵长类动物疾病的发病机制，并评估氟喹诺酮治疗预防致命疾病的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The gram-negative coccobacillus Francisella tularensis is the causative agent of tularemia. The natural reservoir includes small mammals such as ground squirrels, hares, voles, muskrats, water rats, rabbits and other rodents. This illness is spread to humans from infected reservoirs and other small vertebrates through direct contact or transmission from an arthropod vector. Tularemia is manifested in various ways including ulcers at the site of inoculation, pharyngitis, lymphadenopathy, and pneumonia. Immediate treatment with appropriate antibiotics can reduce the possibility of life-threatening pneumonia. F. tularensis is a category A agent. The infectious dose for this agent by inhalation is reported to be as few as 10 organisms. Much less information is known about the mortality of GI tularemia. The ultimate goal for this project is to characterize pathogenesis of disease in nonhuman primates and to assess effectiveness of fluoroquinolone treatment in protecting against lethal disease.