FOOD-BORNE TULAREMIA THREAT ASSESSMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 革兰氏阴性球杆菌土拉热弗朗西斯菌是土拉菌病的病原体。 天然水库包括小型哺乳动物，如地松鼠，野兔，田鼠，麝鼠，水鼠，兔子和其他啮齿动物。 这种疾病通过直接接触或节肢动物媒介传播，从受感染的水库和其他小型脊椎动物传播给人类。 兔热病表现为多种方式，包括接种部位溃疡、咽炎、淋巴结病和肺炎。 立即使用适当的抗生素治疗可以减少危及生命的肺炎的可能性。 F.土拉热是A类病原体。 据报告，吸入该制剂的感染剂量仅为10个微生物。关于胃肠道土拉菌病的死亡率的信息知之甚少。 该项目的最终目标是描述非人灵长类动物疾病的发病机制，并评估氟喹诺酮治疗在预防致命疾病方面的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The gram-negative coccobacillus Francisella tularensis is the causative agent of tularemia. The natural reservoir includes small mammals such as ground squirrels, hares, voles, muskrats, water rats, rabbits and other rodents. This illness is spread to humans from infected reservoirs and other small vertebrates through direct contact or transmission from an arthropod vector. Tularemia is manifested in various ways including ulcers at the site of inoculation, pharyngitis, lymphadenopathy, and pneumonia. Immediate treatment with appropriate antibiotics can reduce the possibility of life-threatening pneumonia. F. tularensis is a category A agent. The infectious dose for this agent by inhalation is reported to be as few as 10 organisms. Much less information is known about the mortality of GI tularemia. The ultimate goal for this project is to characterize pathogenesis of disease in nonhuman primates and to assess effectiveness of fluoroquinolone treatment in protecting against lethal disease.