FOOD-BORNE TULAREMIA THREAT ASSESSMENT

食源性兔热病威胁评估

• 批准号: 8357656
• 负责人: Jean L. Patterson
• 金额: $ 12.84万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357656
• 关键词: Antibiotics; Arthropod Vectors; Breathing; Categories; Disease; Dose; Effectiveness; Fluoroquinolones; Francisella tularensis; Funding; Goals; Grant; Hares; Human; Life; Lymphatic Diseases; Mammals; Microtus; National Center for Research Resources; Ondatra zibethicus; Organism; Oryctolagus cuniculus; Pathogenesis; Pharyngitis; Pneumonia; Primates; Principal Investigator; Rattus; Reporting; Research; Research Infrastructure; Resources; Rodent; Site; Source; Spermophilus; Tularemia; Ulcer; United States National Institutes of Health; Vertebrates; Water; cost; foodborne; mortality; nonhuman primate; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The gram-negative coccobacillus Francisella tularensis is the causative agent of tularemia. The natural reservoir includes small mammals such as ground squirrels, hares, voles, muskrats, water rats, rabbits and other rodents. This illness is spread to humans from infected reservoirs and other small vertebrates through direct contact or transmission from an arthropod vector. Tularemia is manifested in various ways including ulcers at the site of inoculation, pharyngitis, lymphadenopathy, and pneumonia. Immediate treatment with appropriate antibiotics can reduce the possibility of life-threatening pneumonia. F. tularensis is a category A agent. The infectious dose for this agent by inhalation is reported to be as few as 10 organisms. Much less information is known about the mortality of GI tularemia. The ultimate goal for this project is to characterize pathogenesis of disease in nonhuman primates and to assess effectiveness of fluoroquinolone treatment in protecting against lethal disease.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 革兰氏阴性球杆菌土拉弗朗西斯菌是兔热病的病原体。 天然宿主包括小型哺乳动物，如地松鼠、野兔、田鼠、麝香鼠、水鼠、兔子和其他啮齿动物。 这种疾病通过直接接触或节肢动物媒介传播，从受感染的宿主和其他小型脊椎动物传播给人类。 兔热病有多种表现，包括接种部位溃疡、咽炎、淋巴结肿大和肺炎。 立即使用适当的抗生素治疗可以减少危及生命的肺炎的可能性。 F. tularensis 是 A 类病原体。 据报道，这种病原体的吸入感染剂量仅为 10 种生物体。关于胃肠道兔热病死亡率的信息知之甚少。 该项目的最终目标是确定非人类灵长类动物疾病的发病机制，并评估氟喹诺酮治疗预防致命疾病的有效性。