IMAGING OF ORDER AND CHAOS INTISSUE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究利用了最近的证据表明，组织结构和形态的各种元素可以被视为分维对象，并通过适当定义的分维来表征。此外，有证据表明，组织形态和生理的变化伴随着分维的变化，而分维的知识可能提供一个敏感而特异的组织生理状态指标，具有重要的诊断潜力。我们的合作研究旨在探索实验方法，使用非侵入性光学方法来检查模型系统和活体中光吸收和散射特性变化的幅度和空间尺度。未来的研究将探索这种新的组织模型描述如何增强对正在开发的新的虚拟组织模拟器的分析。这种测量将与计算工作相结合，以基于组织的光学吸收和散射属性以及组织的分维的知识来预测光学特征和其他相关组织属性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research takes advantage of recent evidence indicating that various elements of tissue structure and morphology can be treated as fractal objects and characterized by an appropriately defined fractal dimension. Moreover, there is evidence that changes in tissue morphology and physiology are accompanied by changes in the fractal dimension and that knowledge of the fractal dimension may provide a sensitive and specific indicator of tissue physiological state with important diagnostic potential. Our collaborative research intends to explore experimental approaches employing non-invasive optical methods to examine the magnitude and spatial scales of the variation of optical absorption and scattering properties in model systems and in vivo. Future investigations will explore how such new tissue model descriptions might enhance the analysis of a new virtual tissue simulator under development. Such measurements will be combined with computational efforts to predict optical signatures and other relevant tissue properties based on knowledge of optical absorption and scattering properties and the fractal dimension of the tissue.