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STRUCTURAL STUDIES ON COMPLEX METAL-CONTAINING PROTEINS

STRUCTURAL STUDIES ON COMPLEX METAL-CONTAINING PROTEINS
复杂含金属蛋白质的结构研究
批准号：
7721726
负责人：
JOHN W PETERS
金额：
$0.17万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-03-01 至 2009-02-28
来源：
https://reporter.nih.gov/project-details/7721726
关键词：
AddressAlkenesBindingBiochemicalComputer Retrieval of Information on Scientific Projects DatabaseDataEnzymesFundingGoalsGrantHydrogenaseInstitutionKetonesMetalsMethodsNitrogenasePhosphoric Monoester HydrolasesProteinsResearchResearch PersonnelResolutionResourcesSourceStructureUnited States National Institutes of Healthenzyme mechanisminhibitor/antagonistmetal complexnovel

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are using x-ray diffraction methods to address issues concerning the biochemical mechanisms of several metal-containing proteins. In addition to determining the structures of novel enzymes, our main focus is the structural characterization of mechanistic relevant intermediates of various enzymes with the goal of obtaining information concerning enzyme mechanism. Since these studies are often concerned with the characteriztion of bound substrates and inhibitors, the details of their interaction with the enzymes can only be revealed with high resolution x-ray diffraction data. Currently, this approach is being applied to metal-containing hydrogenases and nitrogenases, various phosphatases, and enzymes involved in the bioconversion of alkenes and ketones.
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Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10034848
  • 项目类别：
  • 资助金额：
    $36.72万
  • 财政年份：
    2020
  • 负责人：
    JOHN W PETERS
  • 依托单位：
    WASHINGTON STATE UNIVERSITY
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10874184
  • 项目类别：
  • 资助金额：
    $31.26万
  • 财政年份：
    2020
  • 负责人：
    JOHN W PETERS
  • 依托单位：
    UNIVERSITY OF OKLAHOMA
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10437871
  • 项目类别：
  • 资助金额：
    $3.03万
  • 财政年份：
    2020
  • 负责人：
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  • 依托单位：
    WASHINGTON STATE UNIVERSITY
Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions
  • 批准号：
    10259728
  • 项目类别：
  • 资助金额：
    $35.75万
  • 财政年份：
    2020
  • 负责人：
    JOHN W PETERS
  • 依托单位：
    WASHINGTON STATE UNIVERSITY
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