Magnetic Resonance Imaging-Guided Cancer Interventions

该项目旨在开发和测试受控微创热消融技术，用于治疗占癌症死亡人数四分之一的癌症。我们的目标是提供精确的成像，反馈和控制热损伤的形状和大小，以改善这些患者的治疗选择。 该计划建立在斯坦福大学医学与工程学院，斯坦福大学癌症中心以及UCSF和HeartVista合作者的基础上，汇集了五个项目：1）软组织肿瘤的MR引导HIFU，2）前列腺疾病的微创MRI引导管理，3）腹膜后肿瘤的MR引导精确热治疗，4）用于引导脑中聚焦超声的MRI方法和5）MR引导的RF消融。 这五个项目在方案和基础设施支助方面有许多共同要求，这些要求已合并为核心。工程核心将支持项目2-5的控制硬件和软件，以及改进的设备可视化。体内研究支持核心将协助所有项目进行消融后评估成像、与组织学的相关性和统计支持。 该PPG的结果将是：1）改进微创治疗方案，2）增加对组织对热治疗反应的基础科学理解，3）硬件和软件工程的进步，特别是用于治疗这些癌症。

This project aims to develop and test controlled minimally invasive thermal ablation techniques for the treatment of cancers that are attributed to a quarter of cancer deaths. We aim to provide precise imaging, feedback, and control of the shape and size of thermal lesions to improve the treatment options for these patients. Built upon the foundation of the Stanford Schools of Medicine and Engineering, the Stanford Cancer Center, and collaborators from UCSF and HeartVista, this program brings together five projects: 1) MR-guided HIFU of soft tissue tumors, 2) Minimally Invasive MRI-Guided Management of Prostate Disease, 3) MR-Guided Precision Thermal Therapy of Retroperitoneal Tumors, 4) MRI Methods for Guiding Focused Ultrasound in the Brain and 5) MR-guided RF Ablation. The five projects have many common requirements for programmatic and infrastructure support, which have been consolidated into cores. An engineering core will support Projects 2-5 with control hardware and software, as well as improved device visualization. An in vivo study support core will assist all of the projects with post ablation assessment imaging, correlation with histology, and statistical support. The outcomes of this PPG will be 1) improved minimally-invasive treatment options, 2) an increase in the basic science understanding of tissue response to thermal treatments, and 3) advances in engineering, both hardware and software, specifically for treatment of these cancers.