Magnetic Resonance Imaging-Guided Cancer Interventions

磁共振成像引导的癌症干预

• 批准号: 8152749
• 负责人: Kim Butts-Pauly
• 金额: $ 166.73万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8152749
• 关键词: Ablation; Acoustics; Adverse effects; Algorithms; Animals; Area; Basic Science; Biopsy; Brain; Cadaver; Cancer Center; Cancer Control; Cancer Intervention; Cessation of life; Clinical; Clinical Trials; Computer software; Cryosurgery; Development; Devices; Diagnostic; Doctor of Medicine; Doctor of Philosophy; Doctor of Veterinary Medicine; Effectiveness; Electromagnetic Fields; Engineering; Evaluation; Feedback; Focused Ultrasound Therapy; Foundations; Funding; Gold; Histology; Human; Image; Imagery; In Vitro; Individual; Intervention; Kidney; Lesion; Limb structure; Liver; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of pancreas; Maps; Methods; Monitor; Neoplasms; Operative Surgical Procedures; Organ; Outcome; Pancreas; Pathologic; Patients; Procedures; Prostate; Prostatic Diseases; Prostatic Neoplasms; Radiation; Radiofrequency Interstitial Ablation; Research; Research Infrastructure; Retroperitoneal Space; Robotics; Services; Shapes; Soft Tissue Neoplasms; Structure; Techniques; Technology; Temperature; Testing; Thermal Ablation Therapy; Time; Tissues; Transducers; Translations; Ultrasonography; United States National Institutes of Health; Work; calcification; cancer therapy; clinically significant; density; design; effective therapy; haptics; human subject; improved; in vivo; medical schools; meetings; minimally invasive; new technology; oncology; programs; response; statistics; tumor

This project aims to develop and test controlled minimally invasive thermal ablation techniques for the treatment of cancers that are attributed to a quarter of cancer deaths. We aim to provide precise imaging, feedback, and control of the shape and size of thermal lesions to improve the treatment options for these patients. Built upon the foundation of the Stanford Schools of Medicine and Engineering, the Stanford Cancer Center, and collaborators from UCSF and HeartVista, this program brings together five projects: 1) MR-guided HIFU of soft tissue tumors, 2) Minimally Invasive MRI-Guided Management of Prostate Disease, 3) MR-Guided Precision Thermal Therapy of Retroperitoneal Tumors, 4) MRI Methods for Guiding Focused Ultrasound in the Brain and 5) MR-guided RF Ablation. The five projects have many common requirements for programmatic and infrastructure support, which have been consolidated into cores. An engineering core will support Projects 2-5 with control hardware and software, as well as improved device visualization. An in vivo study support core will assist all of the projects with post ablation assessment imaging, correlation with histology, and statistical support. The outcomes of this PPG will be 1) improved minimally-invasive treatment options, 2) an increase in the basic science understanding of tissue response to thermal treatments, and 3) advances in engineering, both hardware and software, specifically for treatment of these cancers.

该项目旨在开发和测试可控的微创热消融技术，用于治疗四分之一的癌症死亡。我们的目标是提供精确的成像、反馈和控制热病变的形状和大小，以改善这些患者的治疗选择。