MRI Methods for Guiding Focused Ultrasound in the Brain

深层脑瘤的令人兴奋的潜力是用聚焦超声波治疗它们的能力， 不会损伤中间组织，也不需要打开头部。核磁共振可以提供 通过突出的软组织对比剂对这些过程进行必要的控制，以进行靶向、监测 核磁共振测温技术，以及在治疗后立即评估组织活性的方法。这个 本项目的目的是改进这些磁共振方法。具体地说，我们的目标是a)改善焦点 局部化，b)改善温度成像，包括全脑覆盖和降低对 伪影，c)在存在钙化的情况下改善了消融，以及d)测试了一系列 超声波脉冲不会损伤脑组织，热固定的温度高于 60℃。此外，我们还将研究热损在DWI、MT、T1、CE和硬度加权上的表现。 图像。

The exciting potential for deep-seated brain tumors is the ability to treat them with focused ultrasound, without damage to the intervening tissues, and without the need to open the head. MRI can provide the necessary control for these procedures through outstanding soft tissue contrast for targeting, monitoring techniques with MR thermometry, and the means to assess tissue viability immediately after treatment. The aims of this project are to improve these MR methods. Specifically, we aim to a) improve focal spot localization, b) improve temperature imaging including whole brain coverage and reduced sensitivity to artifacts, c) improved ablation in the presence of calcifications, and d) test the hypotheses that a series of ultrasound pulses do not damage brain tissue and that heat fixation occurs for temperatures greater than 60¿C. In addition, we will investigate the appearance of thermal lesions on DWI, MT, T1, CE, and stiffness weighted images.