MR IMAGE GUIDED FOCUSED ULTRASOUND FOR TREATMENT OF LIVER AND RENAL CANCER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 授权编号：5 R 01 CA 121163 -03 项目开始日期：2006年9月28日 项目结束日期：2010年7月31日 该项目的长期目标是开发一种微创治疗上腹部癌症的方法，包括原发性和转移性肝癌以及肾细胞癌。该项目的具体目标是：1）设计、制造和评价用于在MR引导下治疗肝脏和肾脏肿瘤的手持式相控阵聚焦超声治疗探头; 2）开发MRI成像软件，以准确绘制上腹部组织温度; 3）对系统进行初步测试和评价。聚焦超声是下一代非侵入性癌症治疗系统的一种有前途的技术。利用这种技术，超声能量集中在身体深处的一个点，以热消融目标组织。这可以在皮肤表面具有最小的热沉积并且没有皮肤穿刺或切口的情况下完成。这里提出的努力解决了在上腹部使用聚焦超声治疗的主要技术挑战。将开发技术和系统，以将聚焦超声治疗与磁共振图像引导相结合，从而允许将热能精确定位到目标组织。将开发通过精确的温度映射监测热沉积的技术，以确保整个目标体积得到治疗，并确定关键结构（如血管、胆囊和横膈膜）是否保持足够的冷却以避免损伤。由于上腹部的器官在呼吸过程中会移动，因此将开发补偿运动的MRI热成像序列。新技术和系统将在体模上开发，并在猪动物模型上进行测试。相关性：结直肠癌是男性和女性癌症相关死亡的第三大原因。其中许多死亡与结肠直肠转移到肝脏有关。同样，肾细胞癌是一种通常致命的恶性肿瘤，在美国的发病率正在增加。微创热疗法在治疗这些疾病方面显示出有希望的结果，但仍存在许多技术挑战。本文提出的工作解决了这些挑战，如果成功，将代表癌症非侵入性治疗的重大进展。 PI：Kim Butts-Pauly 机构名称： 斯坦福大学，斯坦福，CA 94305

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Grant Number: 5R01CA121163-03 Project Start: 28-SEP-2006 Project End: 31-JUL-2010 The long-term goal of this project is to develop a minimally invasive treatment for cancers in the upper abdomen, including primary and metastatic tumors in the liver, and renal cell carcinoma. Specific aims of the project are to 1) design, fabricate, and evaluate handheld phased array focused ultrasound therapy probes for treating liver and renal tumors under MR guidance, 2) develop MRI imaging software to accurately map the tissue temperature in the upper abdomen, and 3) perform initial testing and evaluation of the system. Focused ultrasound is a promising technique for the next generation of non-invasive cancer therapy systems. With this technology, ultrasound energy is focused at a point deep within the body to thermally ablate targeted tissue. This can be done with minimal heat deposition at the skin surface and without skin puncture or incision. The effort proposed here addresses the main technical challenges to using focused ultrasound therapy in the upper abdomen. Techniques and systems will be developed to couple focused ultrasound treatment with Magnetic Resonance image guidance to allow precise targeting of the thermal energy to target tissues. Techniques to monitor heat deposition through accurate temperature mapping will be developed to insure that the entire target volume is being treated, and to determine if critical structures such as vessels, the gall bladder and the diaphragm remain sufficiently cool to avoid damage. Since organs in the upper abdomen move during breathing, MRI thermal imaging sequences that compensate for motion will be developed. The new techniques and systems will be developed on phantoms and tested in porcine animal models. Relevance: Colorectal cancer is the third leading cause of cancer related deaths in men and women. Many of these deaths are associated with colorectal metastases to the liver. Similarly, renal cell carcinoma is an often fatal malignancy which is increasing in incidence in the US. Minimally invasive thermal therapies are showing promising results in the treatment of these conditions, but many technical challenges remain. The work proposed here addresses these challenges and if successful, will represent a major advance in the non-invasive treatment of cancer. PI: Kim Butts-Pauly Institution: STANFORD UNIVERSITY, STANFORD, CA 94305