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STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS

STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS
使用树枝状脂质扩展膜电荷密度的极限
批准号：
7723559
负责人：
CYRUS R SAFINYA
金额：
$1.26万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-08-01 至 2009-04-30
来源：
https://reporter.nih.gov/project-details/7723559
关键词：
ChargeComputer Retrieval of Information on Scientific Projects DatabaseControlled StudyDNA deliveryFundingGrantHeadInstitutionLipidsMembraneRangeResearchResearch PersonnelResourcesSourceStretchingTransfectionUnited States National Institutes of Healthdensitydesignvector

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Newly designed multivalent lipids ranging in head group charge from 4+ to 16+ have been synthesized and investigated as DNA delivery vectors. These dendritic lipids (DLs) allow a controlled study of the relationship between membrane charge density and transfection efficiency (TE).
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Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS
  • 批准号：
    8362446
  • 项目类别：
  • 资助金额：
    $0.64万
  • 财政年份：
    2011
  • 负责人：
    CYRUS R SAFINYA
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE