课题基金 / 基金详情

STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS

STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS
使用树枝状脂质扩展膜电荷密度的极限
批准号：
8169665
负责人：
CYRUS R SAFINYA
金额：
$1.29万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-05-01 至 2011-04-30
来源：
https://reporter.nih.gov/project-details/8169665
关键词：
ChargeComputer Retrieval of Information on Scientific Projects DatabaseControlled StudyDNA deliveryFundingGrantHeadInstitutionLipidsMembraneResearchResearch PersonnelResourcesSourceStretchingTransfectionUnited States National Institutes of Healthdensitydesignvector

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中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 新设计的头基电荷范围从4到16的多价脂类化合物已经被合成并作为DNA传递载体进行了研究。这些树突状脂类(DL)允许对膜电荷密度和转染率(TE)之间的关系进行对照研究。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Newly designed multivalent lipids ranging in head group charge from 4+ to 16+ have been synthesized and investigated as DNA delivery vectors. These dendritic lipids (DLs) allow a controlled study of the relationship between membrane charge density and transfection efficiency (TE).
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Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS
  • 批准号：
    8362446
  • 项目类别：
  • 资助金额：
    $0.64万
  • 财政年份：
    2011
  • 负责人：
    CYRUS R SAFINYA
  • 依托单位：
    SCRIPPS RESEARCH INSTITUTE, THE