STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS

使用树枝状脂质扩展膜电荷密度的极限

• 批准号: 8362446
• 负责人: CYRUS R SAFINYA
• 金额: $ 0.64万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362446
• 关键词: Charge; Controlled Study; DNA delivery; Dendrimers; Funding; Grant; Head; Lipids; Membrane; Microscopy; Molecular; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Stretching; Transfection; United States National Institutes of Health; cost; density; design; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Newly designed multivalent lipids ranging in head group charge from 4+ to 16+ have been synthesized and investigated as DNA delivery vectors. These dendritic lipids (DLs) allow a controlled study of the relationship between membrane charge density and transfection efficiency (TE).

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 新设计的头基电荷从4+到16+的多价脂类已经被 合成并研究了其作为DNA递送载体。这些树突状脂质(DLS)允许 膜电荷密度与转染率关系的对照研究 效率(TE)。