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STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS

STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS
使用树枝状脂质扩展膜电荷密度的极限
批准号：
8362446
负责人：
CYRUS R SAFINYA
金额：
$0.64万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-05-01 至 2012-04-30
来源：
https://reporter.nih.gov/project-details/8362446
关键词：
ChargeControlled StudyDNA deliveryDendrimersFundingGrantHeadLipidsMembraneMicroscopyMolecularNational Center for Research ResourcesPrincipal InvestigatorResearchResearch InfrastructureResourcesSourceStretchingTransfectionUnited States National Institutes of Healthcostdensitydesignvector

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中文摘要
翻译
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Newly designed multivalent lipids ranging in head group charge from 4+ to 16+ have been synthesized and investigated as DNA delivery vectors. These dendritic lipids (DLs) allow a controlled study of the relationship between membrane charge density and transfection efficiency (TE).
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Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
Functionalized Lipid Carriers for Nucleic-Acid and Drug Therapeutics
SYNCHROTRON X-RAY STUDIES OF BIOMOLECULAR MATERIALS
  • 批准号：
    8362233
  • 项目类别：
  • 资助金额：
    $2.25万
  • 财政年份：
    2011
  • 负责人：
    CYRUS R SAFINYA
  • 依托单位：
    STANFORD UNIVERSITY
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