STRETCHING THE LIMITS OF MEMBRANE CHARGE DENSITY USING DENDRIMER LIPIDS

使用树枝状脂质扩展膜电荷密度的极限

• 批准号: 7602741
• 负责人: CYRUS R SAFINYA
• 金额: $ 1.79万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-13 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7602741
• 关键词: Charge; Computer Retrieval of Information on Scientific Projects Database; Controlled Study; DNA delivery; Funding; Grant; Head; Institution; Lipids; Membrane; Range; Research; Research Personnel; Resources; Source; Stretching; Transfection; United States National Institutes of Health; density; design; vector

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Newly designed multivalent lipids ranging in head group charge from 4+ to 16+ have been synthesized and investigated as DNA delivery vectors. These dendritic lipids (DLs) allow a controlled study of the relationship between membrane charge density and transfection efficiency (TE).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 新设计的多价脂质的头部基团电荷范围从4+到16+已被合成和研究作为DNA递送载体。这些树突状脂质（DLs）允许膜电荷密度和转染效率（TE）之间的关系的受控研究。