CELL MIGRATION CONSORTIUM PROJECT

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goals for correlation microscopy are to develop a toolbox for analyzing image sequences for: a) extracting protein binding dynamics using raster image correlation (RICS) and TIRF time correlation microscopy, b) identifying molecular associations by two color cross-correlation methods, c) determining protein aggregation states by intensity brightness analysis of analog signals, and d) developing spatial-temporal correlation analyses for measuring adhesion assembly and disassembly rates and rates and directions of movement.