ROLE OF ION FLUXES DURING PATTERNING & EMBRYOGENESIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 我们正在探索离子通量在两个脊椎动物发育阶段的深刻作用：在早期胚胎发育过程中左-右（LR）轴的建立和模式，以及在截肢附肢再生过程中皮肤，肌肉，骨骼和脊髓的再生。 (See SPID 0104）这两个过程作为问题都很吸引人，并且对于指导生物医学方法的设计至关重要，在LR模式的情况下，纠正出生缺陷（如左心发育不良综合征，异位，无脾，多脾，主要血管转位，内脏逆位等）。这两种疾病加在一起会影响超过八千分之一的新生儿，在再生的情况下，通过利用身体潜在的再生组织的能力来替换患病或受损的组织。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are exploring the profound roles of ion fluxes during two vertebrate developmental stages: the establishment and patterning of the left-right (LR) axis during early embryogenesis, and the regeneration of skin, muscle, skeleton, and spinal cord during regeneration of an amputated appendage. (See SPID 0104) Both of these processes are fascinating as questions, and critically important for guiding the design of biomedical approaches to, in the case of LR patterning, correct birth defects (such as Hypoplastic Left Heart Syndrome, heterotaxy, asplenia, polysplenia, transposition of the major blood vessels, situs inversus, etc.) which together affect more than 1 in 8000 births, and, in the case of regeneration, to replace diseased or damaged tissue by harnessing the body's latent ability to recreate tissue.