STRUCTURAL MRI OUTCOME PREDICTORS IN MCI

MCI 中的结构性 MRI 结果预测因素

• 批准号: 7724338
• 负责人: LIANA G APOSTOLOVA
• 金额: $ 0.26万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724338
• 关键词: Admission activity; Biological; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Impairment; Individual; Institution; Intervention; Manic; Mental Depression; Neurocognitive; Outcome; Patients; Pharmacotherapy; Recovery; Recovery of Function; Rehabilitation therapy; Research; Research Personnel; Residual state; Resources; Source; Structure; Testing; Time; United States National Institutes of Health; design; follow-up; functional disability; functional outcomes; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'This project proposes to study biological and clinical correlates of functional recovery in bipolar subjects after an admission for mania. Specifically, we will explore whether neurocognitive, neuroanatomical or subsyndromal depression variables predict time to functional recovery or persistent functional impairment. We will 1) use a cross-sectional design to test specific hypotheses about factors that may discriminate between bipolar individuals who have concurrent functional recovery with symptomatic recovery versus those whose functional impairment persists after symptomatic recovery; 2) use a prospective design with multiple assessments over time in those patients who are functionally impaired at the time of symptomatic recovery to carefully track the temporal relationship (lag) between symptomatic recovery and functional recovery and test specific hypotheses about predictors of eventual functional recovery, and 3) contrast extreme outcome groups (i.e. those who have rapid functional recovery and those with markedly persistent residual impairment) to explore a hypothesis about brain structure and function in the two groups. An important feature of this study is that it will be done in the context of continuous, competent pharmacotherapy follow-up, thus reducing the potential for functional outcome to be confounded by suboptimal treatment and/or non-compliance. Identifying predictors of functional disability would be a first step toward understanding how and why functional impairment occurs; and would allow for appropriate rehabilitation/intervention strategies to be developed.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 “这个项目计划研究躁狂症患者入院后功能恢复的生物学和临床相关性。”具体地说，我们将探索神经认知、神经解剖学或亚综合征抑郁症变量是否预测功能恢复或持续性功能障碍的时间。我们将1)使用横断面设计检验可能区分同时有症状恢复的双相患者和症状恢复后持续功能损害的双相患者的因素的特定假设；2)使用前瞻性设计，在症状恢复时功能受损的患者中使用随时间推移进行多项评估的前瞻性设计，仔细跟踪症状恢复和功能恢复之间的时间关系(滞后)，并测试有关最终功能恢复预测因素的特定假设；以及3)对比极端结果组(即功能恢复迅速和明显持续残留损害的组)，探索关于两组大脑结构和功能的假设。这项研究的一个重要特点是，它将在持续的、称职的药物治疗随访的背景下进行，从而减少因次优治疗和/或不依从性而混淆功能结果的可能性。确定功能性残疾的预测因素将是了解功能障碍如何和为什么发生的第一步；并将允许制定适当的康复/干预策略。