STRUCTURAL STUDIES OF BRCT RECOGNITION OF PHOSPHOPROTEINS

BRCT 磷酸蛋白识别的结构研究

• 批准号: 7721202
• 负责人: NIKOLA P PAVLETICH
• 金额: $ 0.97万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721202
• 关键词: Binding; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Pathway interactions; Phosphoproteins; Physiological; Proteins; Research; Research Personnel; Resources; Single-Stranded DNA; Source; Structure; United States National Institutes of Health; homologous recombination

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brca2 is believed to be a critical component in homologous recombination pathway. We have shown how th c-terminal of Brca2 binds with single strand DNA. In order to understand its physiological function, we would like to determine structure of Brca2 protein with its recognized substrate and interacting partners, including rad51.

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