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STRUCTURAL STUDIES OF BRCT RECOGNITION OF PHOSPHOPROTEINS

STRUCTURAL STUDIES OF BRCT RECOGNITION OF PHOSPHOPROTEINS
BRCT 磷酸蛋白识别的结构研究
批准号:
7369493
负责人:
NIKOLA P PAVLETICH
金额:
$0.18万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-06-01 至 2007-05-31

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项目成果

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中文摘要
翻译
这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金,因此可能会出现在其他CRISE条目中。列出的机构是针对中心的,而不一定是针对调查员的机构。BRCA2被认为是同源重组途径中的关键成分。我们已经展示了BRCA2的C末端是如何与单链DNA结合的。为了了解BRCA2的生理功能,我们想要确定BRCA2蛋白及其识别底物和相互作用伙伴的结构,包括RAD51。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Brca2 is believed to be a critical component in homologous recombination pathway. We have shown how th c-terminal of Brca2 binds with single strand DNA. In order to understand its physiological function, we would like to determine structure of Brca2 protein with its recognized substrate and interacting partners, including rad51.
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Structural Mechanisms of DNA Damage Sensing and Activation of the ATR, Fanconi Anemia, and ATM Checkpoints
  • 批准号:
    10639156
  • 项目类别:
  • 资助金额:
    $67.26万
  • 财政年份:
    2023
  • 负责人:
    NIKOLA P PAVLETICH
  • 依托单位:
STRUCTURAL STUDIES OF DNA REPAIR PROTEINS
  • 批准号:
    8361613
  • 项目类别:
  • 资助金额:
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  • 财政年份:
    2011
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  • 依托单位:
STRUCTURAL STUDIES OF DNA REPAIR PROTEINS
  • 批准号:
    8169225
  • 项目类别:
  • 资助金额:
    $5.46万
  • 财政年份:
    2010
  • 负责人:
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  • 依托单位:
STRUCTURAL STUDIES OF DNA REPAIR PROTEINS
  • 批准号:
    7955104
  • 项目类别:
  • 资助金额:
    $27.63万
  • 财政年份:
    2009
  • 负责人:
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海外基金