THE MULTIPLE ENDOCRINE NEOPLASIA TYPE I (MEN1) TUMOR SUPPRESSOR

I 型多发性内分泌肿瘤 (MEN1) 肿瘤抑制剂

• 批准号: 7721192
• 负责人: NIKOLA P PAVLETICH
• 金额: $ 0.97万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721192
• 关键词: Biochemical; Computer Retrieval of Information on Scientific Projects Database; Data; Disease; Endocrine; Endocrine Gland Neoplasms; Funding; Genetic; Grant; Growth; Institution; Link; Malignant Neoplasms; Menin; Mutation; NF-kappa B; Neoplasms; Numbers; Research; Research Personnel; Resources; Role; Source; Tissues; Tumor Suppressor Proteins; United States National Institutes of Health; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple Endocrine Neoplasia Type (MEN) is an automsomal dominant malignancy that is characterized by tumors of endocrine tissues. The genetic mechanism responsible for this malignancy has been linked to mutations of the Menin tumor suppressor. Despite the wealth of genetic data that support Menin?s role in MEN1 disease, the biochemical function of Menin is still unknown. However, recent studies have demonstrated that the tumor suppressor function of Menin resides in its ability to repress the transcriptional activity of a number of growth-promoting transcription factors, including JunD, Smad3 and NF-kB.

这个子项目是众多研究子项目之一