THE MULTIPLE ENDOCRINE NEOPLASIA TYPE I (MEN1) TUMOR SUPPRESSOR

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple Endocrine Neoplasia Type (MEN) is an automsomal dominant malignancy that is characterized by tumors of endocrine tissues. The genetic mechanism responsible for this malignancy has been linked to mutations of the Menin tumor suppressor. Despite the wealth of genetic data that support Menin?s role in MEN1 disease, the biochemical function of Menin is still unknown. However, recent studies have demonstrated that the tumor suppressor function of Menin resides in its ability to repress the transcriptional activity of a number of growth-promoting transcription factors, including JunD, Smad3 and NF-kB.