STRUCTURE OF A RAD4-RAD23 COMPLEX BOUND TO DNA

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The RAD4 (yeast homolog of human Xeroderma Pigmentosum C)-RAD23 complex acts early on in the global genome NER pathway, in parallel to DDB1-DDB2, to recognize DNA lesions such as 6-4 photoproduct and bulky base adducts. How a variety of chemically diverse lesions is recognized and handed to the rest of NER repair machinery are the major questions we are attempting to address by solving crystal structure of the protein complex bound to its cognate DNA.