A Wireless Small Animal Monitor

无线小动物监视器

• 批准号: 7909528
• 负责人: B EUGENE PARKER
• 金额: $ 54.07万
• 依托单位: BARRON ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7909528
• 关键词: Accreditation; Animal Experiments; Animal Housing; Animal Welfare; Animals; Anus; Archives; Area; Behavioral Sciences; Charge; Collaborations; Communication; Computer software; Computers; Conscious; Contractor; Custom; Data; Data Display; Development; Devices; Docking; Dorsal; Elderly; Electrocardiogram; Electronics; Engineering; Environmental Impact; Evaluation Methodology; Event; Faculty; Figs - dietary; Freedom; Gait; Goals; Graph; Heart Rate; Hour; Housing; Individual; Information Systems; Institutes; International; Internet; Investigation; Laboratories; Laboratory Animals; Life; Lithium; Marketing; Measures; Mechanics; Methods; Monitor; Motion; Mus; Operative Surgical Procedures; Phase; Physical activity; Physiologic Monitoring; Physiological; Polymers; Process; Protocols documentation; Rattus; Research; Research Design; Resistance; Rodent; Running; Safety; Services; Skin Temperature; Small Business Innovation Research Grant; Solutions; Stream; Surface; System; Temperature; Testing; Time; United States National Institutes of Health; Universities; Vertebrates; Virginia; Visual; Wireless Technology; Work; animal care; base; checkup examination; cost; design; falls; implantation; improved; innovation; instrument; instrumentation; monitoring device; programs; public health relevance; remote sensing; research and development; research study; respiratory; sensor; skills; success; usability; wireless fidelity

DESCRIPTION (provided by applicant): The proposed Phase II research program focuses on the development of a wireless Small Animal Physiological Monitor (SAM). The SAM system will provide the capability to monitor up to 16 laboratory animals (initially rats and mice) simultaneously, with continuous recording, synchronization, and display of physiological data, including heart rate, respiratory rate, motion activity, skin temperature, and ambient temperature. Data will be collected from each animal via a miniature, lightweight "backpack" that is worn on the dorsal surface of the animal, with sensors integrated into an appropriately-sized, chew-resistant design. Optional wireless cameras can be mounted in laboratories or animal housing areas and integrated into the SAM system for remote visual monitoring of animals in real time. SAM system data (both physiological and video data) will be uploaded wirelessly to a shared receiver unit that interfaces to a PC (which can be local or over the Internet). The PC will consolidate the incoming data stream(s), archive all data on a hard disk, and provide real-time data display, enabling remote, simultaneous monitoring of all instrumented animals. The proposed Phase II research follows a successful Phase I effort that demonstrated proof of concept and feasibility for the SAM system in both anesthetized (supine) and conscious (prone) rats and mice. The Phase II research will involve creation of a fully-functional, commercially-viable SAM system that will be evaluated in laboratory experiments conducted on a variety of rats and mice, including several animals simultaneously over a one-week period. The SAM system will significantly refine animal welfare for many research experiments by eliminating the need for surgical implantation of sensors and providing the capability for wireless monitoring of key physiological variables. PUBLIC HEALTH RELEVANCE: The SAM system will provide improved instrumentation that will facilitate biomedical and behavioral science investigations across essentially all NIH institutes, as rats and mice are the most commonly used vertebrates in research. Additionally, the SAM system will enable research in areas that are presently constrained by the absence of suitable monitoring devices. For example, many questions regarding housing and husbandry practices of rodents and the impact of environmental conditions and/or external events on these animals remain unanswered.

描述（由申请人提供）：拟议的第二阶段研究计划重点开发无线小动物生理监测仪（SAM）。 SAM 系统将能够同时监测多达 16 只实验动物（最初是大鼠和小鼠），并连续记录、同步和显示生理数据，包括心率、呼吸频率、运动活动、皮肤温度和环境温度。数据将通过佩戴在动物背部表面的微型、轻质“背包”从每只动物身上收集，传感器集成到适当尺寸、耐咀嚼的设计中。可选的无线摄像头可以安装在实验室或动物饲养区，并集成到 SAM 系统中，对动物进行实时远程视觉监控。 SAM 系统数据（生理数据和视频数据）将通过无线方式上传到与 PC（可以是本地的或通过互联网）连接的共享接收器单元。 PC 将整合传入的数据流，将所有数据存档在硬盘上，并提供实时数据显示，从而实现对所有仪器动物的远程同步监控。 拟议的 II 期研究是在 I 期研究成功之后进行的，该研究在麻醉（仰卧）和清醒（俯卧）大鼠和小鼠中证明了 SAM 系统的概念和可行性。第二阶段研究将涉及创建一个功能齐全、具有商业可行性的 SAM 系统，该系统将在实验室对各种大鼠和小鼠进行的实验中进行评估，其中包括在一周内同时对几只动物进行的实验。 SAM 系统无需通过手术植入传感器，并提供无线监测关键生理变量的能力，将显着改善许多研究实验的动物福利。 公共健康相关性：SAM 系统将提供改进的仪器，促进几乎所有 NIH 研究所的生物医学和行为科学研究，因为大鼠和小鼠是研究中最常用的脊椎动物。此外，SAM 系统将使目前因缺乏合适的监测设备而受到限制的领域的研究成为可能。例如，关于啮齿类动物的饲养和饲养方式以及环境条件和/或外部事件对这些动物的影响的许多问题仍未得到解答。