OBESITY, ADIPOGENESIS, AND LIPID LIGANDS
肥胖、脂肪生成和脂质配体
基本信息
- 批准号:7855309
- 负责人:
- 金额:$ 38万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-04-15 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:2,4-thiazolidinedioneAdipocytesAdipose tissueAffectAmericanAnimalsArthritisAutomobile DrivingBindingBinding SitesBlood GlucoseCellsConsciousControl AnimalDataDevelopmentDiabetes MellitusDietDiseaseDrug Delivery SystemsEatingEmbryoEnzymesEpidemicExerciseFatty acid glycerol estersFatty-acid synthaseFibroblastsGeneticGenetic TranscriptionHealthHeart DiseasesHyperlipidemiaHypertensionHypertrophyIndividual DifferencesInflammationKnock-outLeadLecithinLigandsLipid BindingLipidsLiverLuciferasesMalignant NeoplasmsMass Spectrum AnalysisMediatingMetabolicMetabolic DiseasesMetabolismMissionModelingMusNon-Insulin-Dependent Diabetes MellitusNuclear ReceptorsNutritionalObesityObesity associated diseasePathway interactionsPeroxisome Proliferator-Activated ReceptorsPhenotypePlasmidsPredispositionProcessPublic HealthQuality of lifeReceptor ActivationReporterResearchResistanceRoleSerumSignal TransductionSleep Apnea SyndromesStrokeTechniquesTestingThiazolidinedionesTissuesTranscriptional ActivationUnited States National Institutes of HealthVascular DiseasesWorkadipocyte differentiationdiabetes mellitus therapydisorder riskenergy balancefeedingglucose metabolismimprovedin vivoinnovationlipid biosynthesismembernovelnovel strategiesobesity riskprogramspublic health relevancereceptorreceptor bindingwillingness
项目摘要
DESCRIPTION (provided by applicant): Obesity and its sequelae including diabetes are epidemic. Manipulating fat cells could lead to new therapies for obesity-associated disease. Peroxisome proliferator-activated receptors (PPARs) are involved in obesity and diabetes. One of these receptors, PPAR, is required for adipogenesis. Identification of endogenous PPAR ligands has been elusive. We have now identified an endogenous ligand for PPAR and developed an analogous strategy for identifying endogenous PPAR ligands. This work was predicated on the finding that inactivation of fatty acid synthase (FAS) in mouse liver produces a phenotype resembling PPAR deficiency that is rescued by pharmacologic activation of PPAR. Mass spectrometry techniques identified a lipid bound to PPAR that was FAS-dependent. This application focuses on obesity-resistant animals with FAS deficiency in adipose tissue, FASKOF (Fatty Acid Synthase KnockOut in Fat) mice. FAS-deficient embryonic fibroblasts have a phenotype resembling PPAR deficiency that is rescued by pharmacologic activation of PPAR. This project will test the hypothesis that in adipose tissue and its precursors, fatty acid synthase, an enzyme required for the process of de novo lipogenesis, mediates risk for obesity and metabolic disease in part by activating the nuclear receptor PPAR. The specific aims are: 1. To determine if mice with FAS inactivation in adipose tissue (FASKOF mice) are protected from diet- induced and genetic obesity and if pharmacologic activation of PPAR reverses protection. 2. To determine if the presence of FAS is required for PPAR activation and the normal adipocyte differentiation process. 3. To use mass spectrometry analyses to identify potential endogenous PPAR ligands by comparing lipids bound to PPAR isolated from FASKOF (FAS-deficient) and control (FAS-replete) cells. This project has the potential to help clarify how endogenous ligands are generated for a nuclear receptor implicated in the modulation of adiposity, glucose metabolism and inflammation.
PUBLIC HEALTH RELEVANCE: This application is relevant to public health and the mission of the NIH. Obesity shortens and diminishes the quality of life through its association with diabetes, heart disease and stroke, arthritis, sleep apnea, certain cancers, and other disorders. Identifying novel pathways for altering the function of fat cells has the potential to improve the metabolic milieu of obesity and treat obesity-associated diseases.
描述(申请人提供):肥胖及其后遗症,包括糖尿病,是流行病。操纵脂肪细胞可能会导致肥胖相关疾病的新疗法。过氧化物酶体增殖物激活受体(PPAR)与肥胖和糖尿病有关。其中一种受体,PPAR,是脂肪生成所必需的。内源性PPAR配体的鉴定一直难以捉摸。我们现在已经确定了PPAR的内源性配体,并开发了一种类似的策略来识别内源性PPAR配体。这项工作的基础是发现小鼠肝脏中脂肪酸合成酶(Fas)的失活会产生一种类似于PPAR缺乏症的表型,这种表型可以通过PPAR的药物激活来挽救。质谱学技术鉴定出一种与PPAR结合的脂质是依赖于Fas的。这项应用主要针对脂肪组织中Fas缺乏的肥胖抵抗动物,FASKOF(脂肪中的脂肪酸合成酶基因敲除)小鼠。Fas缺陷的胚胎成纤维细胞具有类似于PPAR缺陷的表型,可通过PPAR的药物激活来挽救。这个项目将检验这样的假设:在脂肪组织及其前体中,脂肪酸合成酶,一种从头生成脂肪的过程中所需的酶,部分通过激活核受体PPAR来调节肥胖和代谢性疾病的风险。其具体目的是:1.确定脂肪组织中Fas失活的小鼠(FASKOF小鼠)是否对饮食诱导的和遗传性肥胖具有保护作用,以及PPAR的药物激活是否逆转了保护作用。2.确定PPAR激活和正常脂肪细胞分化过程是否需要Fas的存在。3.通过比较FASKOF(Fas-缺失)和对照(Fas-Replete)细胞分离的PPAR结合的脂类,利用质谱分析鉴定潜在的内源性PPAR配体。这个项目有可能帮助阐明核受体的内源性配体是如何产生的,核受体与肥胖、葡萄糖代谢和炎症的调节有关。
公共卫生相关性:这项申请与公共卫生和美国国立卫生研究院的使命相关。肥胖与糖尿病、心脏病和中风、关节炎、睡眠呼吸暂停、某些癌症和其他疾病有关,从而缩短和降低生活质量。寻找改变脂肪细胞功能的新途径,有可能改善肥胖的代谢环境,治疗肥胖相关疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Clay F. Semenkovich其他文献
Fatty Acid Synthase Targeting Reduces Aortic Atherosclerosis and Inflammation
- DOI:
10.1016/j.jvssci.2023.100138 - 发表时间:
2023-01-01 - 期刊:
- 影响因子:
- 作者:
Rodrigo Meade;Connor Engel;Larisa Belaygorod;Batool Arif;Wahid Abu-Amer;Clay F. Semenkovich;Mohamed A. Zayed - 通讯作者:
Mohamed A. Zayed
Mutants of Volvox carteri affecting nitrogen assimilation
- DOI:
10.1007/bf00271666 - 发表时间:
1979-01-01 - 期刊:
- 影响因子:2.100
- 作者:
Robert J. Huskey;Clay F. Semenkovich;Barbara E. Griffin;Patricia O. Cecil;Ann M. Callahan;Kenneth V. Chace;David L. Kirk - 通讯作者:
David L. Kirk
Genetic deletion of fatty acid synthase in vascular smooth muscle cell suppresses injury-induced neointima formation in mice
血管平滑肌细胞脂肪酸合酶的基因缺失抑制小鼠损伤诱导的新内膜形成
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Naomi Oshima;Hiroki Matsui;Hiroaki Sunaga;Tatsuya Iso;Clay F. Semenkovich;Masahiko Kurabayashi;Tomoyuki Yokoyama - 通讯作者:
Tomoyuki Yokoyama
Palmitoylation couples insulin hypersecretion with β cell failure in diabetes
棕榈酰化将糖尿病中胰岛素的高分泌与β细胞衰竭联系起来
- DOI:
10.1016/j.cmet.2022.12.012 - 发表时间:
2023-02-07 - 期刊:
- 影响因子:30.900
- 作者:
Guifang Dong;Sangeeta Adak;George Spyropoulos;Qiang Zhang;Chu Feng;Li Yin;Sarah L. Speck;Zeenat Shyr;Shuntaro Morikawa;Rie Asada Kitamura;Rahul S. Kathayat;Bryan C. Dickinson;Xue Wen Ng;David W. Piston;Fumihiko Urano;Maria S. Remedi;Xiaochao Wei;Clay F. Semenkovich - 通讯作者:
Clay F. Semenkovich
Inhibition of fatty acid synthase plays a protective role in vascular smooth muscle cell proliferation and neointimal formation.
抑制脂肪酸合酶在血管平滑肌细胞增殖和新内膜形成中发挥保护作用。
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Naomi Oshima;Hiroki Matsui;Hiroaki Sunaga;Tatsuya Iso;Clay F. Semenkovich;Tomoyuki Yokoyama;Masahiko Kurabayashi. - 通讯作者:
Masahiko Kurabayashi.
Clay F. Semenkovich的其他文献
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{{ truncateString('Clay F. Semenkovich', 18)}}的其他基金
GLUCOCORTICOID RECEPTOR POST-TRANSLATIONAL MODIFICATIONS IN INSULIN RESISTANCE
胰岛素抵抗中的糖皮质激素受体翻译后修饰
- 批准号:
9980364 - 财政年份:2016
- 资助金额:
$ 38万 - 项目类别:
MODULATING PHYSIOLOGIC EFFECTS OF PHOSPHOLIPID METABOLISM IN OBESITY AND DIABETES
调节磷脂代谢对肥胖和糖尿病的生理影响
- 批准号:
8885119 - 财政年份:2015
- 资助金额:
$ 38万 - 项目类别:
MODULATING PHYSIOLOGIC EFFECTS OF PHOSPHOLIPID METABOLISM IN OBESITY AND DIABETES
调节磷脂代谢对肥胖和糖尿病的生理影响
- 批准号:
9221327 - 财政年份:2015
- 资助金额:
$ 38万 - 项目类别:
MACROPHAGE FATTY-ACID SYNTHASE DEFICIENCY DECREASES DIET-INDUCED ATHEROSCLEROSIS
巨噬细胞脂肪酸合酶缺乏可减少饮食引起的动脉粥样硬化
- 批准号:
8361454 - 财政年份:2011
- 资助金额:
$ 38万 - 项目类别:
相似国自然基金
支链氨基酸代谢紊乱调控“Adipocytes - Macrophages Crosstalk”诱发2型糖尿病脂肪组织功能和结构障碍的作用及机制
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- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
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