Diabetes and Related Metabolic Diseases

 描述(由申请人提供)： 这一竞争性续签申请代表着华盛顿大学两个成功的糖尿病研究培训项目--DK007120(设在医学系)和KD007296(设在病理与免疫学系)--合并为一个名为糖尿病及相关代谢疾病(DK007120)的项目。在超过35年的时间里，这两个T32项目培养了大量的生物医学科学家，他们对糖尿病有了重要的见解。为了继续培训能够开发新方法来应对糖尿病及其并发症显著增加的杰出科学家和医生，我们将这两个长期项目整合为一个项目。这一合并计划的目标是提供从模型系统到结果研究的指导专业知识，在一个滋养的、结构化的环境中进行研究，这将培养出独立的糖尿病科学家，可能改变糖尿病及其并发症的研究格局。该计划由两个具有互补技能的PI指导，一个是免疫学，另一个是新陈代谢，以促进在新兴的免疫新陈代谢领域的培训机会。合并后的项目是华盛顿大学唯一由美国国立卫生研究院支持的糖尿病博士后培训机制。该计划根据我们对其有效性、受训人员的需求以及糖尿病研究的动态性质的持续评估而不断发展。它是多学科的，以团队为导向。我们建议通过一个结构化的计划继续培训MD、MD博士和博士科学家2-3年，该计划利用了许多优势，包括但不限于：·一个由29名专注于糖尿病的特殊导师组成的人才库。这些科学家正在进行基本机制的研究，T1翻译原则的证明，T2/T3翻译给患者和实践，以及T3/T4翻译到实践和人群。该小组包括国家科学院的两名成员和医学研究所的一名成员，每个成员都在最近的资助期间指导了受训人员，以及几名代表广泛职业阶段和多样性的新成员。·要求所有受训人员开设糖尿病科学核心课程，以确保具有不同背景的个人建立一个标准的知识库。·对博士科学家和拥有临床学位的科学家进行临床背景培训 为翻译工作提供信息。·明确定义的成功指标，由针对每个学员的个性化职业发展委员会进行监控。·评估方案质量和有效性的一系列机制，以及针对这些评估工具的结果采取行动的既定程序。·与我们的NIDDK糖尿病研究中心密切合作，实施动态整合的短期研究培训计划。·完善的增强多样性的机制。我们的学员很有成效，在过去10年里发表了250多篇论文，被引用超过8000次。他们成功地为他们的研究获得了赠款支持，这些研究包括(在过去10年)两个R01，几个R01等效物(在欧盟)，三个K01，两个K12，两个KL2，一个K99/R00，几个试点和可行性奖，美国糖尿病协会和美国心脏协会的奖项，以及其他。他们在实现富有成效的科学事业方面是成功的，因为根据NIH引用的数据，我们的受训人员进入学术界的速度(根据学位)比生物医学劳动力高出约50%-100%(取决于学位)。我们对两个项目的整合取得了协同效应，从而改善了导师库，增强了招聘和指导战略，并扩大了增加多样性的努力，共同延续了多学科培训的文化，极有可能对糖尿病研究产生持续而强大的影响。

 DESCRIPTION (provided by applicant): This competitive renewal application represents the merger of two successful diabetes research training programs at Washington University, DK007120 (based in the Department of Medicine) and KD007296 (based in the Department of Pathology & Immunology), into a single program entitled Diabetes and Related Metabolic Diseases (DK007120). For more than 35 years, these two T32 programs have trained a large number of biomedical scientists who have generated important insights into diabetes. To continue training outstanding scientists and physicians capable of developing novel approaches to address the striking increase in diabetes and its complications, we have integrated these two longstanding programs into one. The goal of this merged program is to provide mentoring expertise spanning model systems to outcomes research within a nurturing, structured environment that will produce independent diabetes scientists likely to change the landscape of research in diabetes and its complications. The program is directed by two PIs with complementary skill sets, one in immunology, the other in metabolism, to facilitate training opportunities in the emerging field of immunometabolism. The merged program represents the only NIH-supported mechanism for postdoctoral training in diabetes research at Washington University. The program is continually evolving in response to our ongoing assessment of its effectiveness, the needs of our trainees, and the dynamic nature of diabetes research. It is multidisciplinary and team-oriented. We propose to continue to train MD, MD PhD, and PhD scientists for 2-3 years through a structured program that leverages numerous strengths that include but are not limited to: • An exceptional pool of 29 mentors focused on diabetes. These scientists are pursuing research in basic mechanisms, proof of principle T1 translation, T2/T3 translation to patients and practice, and T3/T4 translatio to practice and populations. This group includes two members of the National Academy of Sciences and one member of the Institute of Medicine, each having mentored trainees during this most recent funding period, and several new members representing a broad spectrum of career stage and diversity. • A core curriculum in diabetes science required of all trainees to ensure that individuals with different backgrounds establish a standard knowledge base. • Training with a clinical context for PhD scientists as well as those with clinical degrees in order to inform translational efforts. • Clearly defined metrics of success that are monitored by a personalized Career Development Committee for each trainee. • A series of mechanisms to assess quality and effectiveness of the program as well as established procedures to take action in response to the results of these assessment tools. • A dynamically integrated short-term research training program operated in close collaboration with our NIDDK Diabetes Research Center. • Well-established mechanisms for enhancing diversity. Our trainees are productive, having published more than 250 papers that have been cited more than 8000 times in the past 10 years. They are successful in terms of obtaining grant support for their research that includes (in the past 10 years) two R01s, several R01 equivalents (in the EU), three K01s, two K12s, two KL2s, one K99/R00, several pilot and feasibility awards, awards from the American Diabetes Association and the American Heart Association, and others. They are successful in terms of achieving productive scientific careers since our trainees enter academics (in the past 10 years) at a rate ~50-100% greater (depending on degree) than the biomedical workforce based on data cited by NIH. Our integration of two programs has achieved synergies leading to improvements in the mentor pool, enhancements in recruitment and mentoring strategies, and expanded efforts to increase diversity that collectively perpetuate a culture of multidisciplinary training with a very high likelihood of exerting a sustained and powerful influence on diabetes research.