Diabetes and Related Metabolic Diseases

糖尿病及相关代谢疾病

• 批准号: 9429380
• 负责人: Clay F. Semenkovich
• 金额: $ 1.12万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-11 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9429380
• 关键词: Diabetes Mellitus; Metabolic Diseases

 DESCRIPTION (provided by applicant): This competitive renewal application represents the merger of two successful diabetes research training programs at Washington University, DK007120 (based in the Department of Medicine) and KD007296 (based in the Department of Pathology & Immunology), into a single program entitled Diabetes and Related Metabolic Diseases (DK007120). For more than 35 years, these two T32 programs have trained a large number of biomedical scientists who have generated important insights into diabetes. To continue training outstanding scientists and physicians capable of developing novel approaches to address the striking increase in diabetes and its complications, we have integrated these two longstanding programs into one. The goal of this merged program is to provide mentoring expertise spanning model systems to outcomes research within a nurturing, structured environment that will produce independent diabetes scientists likely to change the landscape of research in diabetes and its complications. The program is directed by two PIs with complementary skill sets, one in immunology, the other in metabolism, to facilitate training opportunities in the emerging field of immunometabolism. The merged program represents the only NIH-supported mechanism for postdoctoral training in diabetes research at Washington University. The program is continually evolving in response to our ongoing assessment of its effectiveness, the needs of our trainees, and the dynamic nature of diabetes research. It is multidisciplinary and team-oriented. We propose to continue to train MD, MD PhD, and PhD scientists for 2-3 years through a structured program that leverages numerous strengths that include but are not limited to: • An exceptional pool of 29 mentors focused on diabetes. These scientists are pursuing research in basic mechanisms, proof of principle T1 translation, T2/T3 translation to patients and practice, and T3/T4 translatio to practice and populations. This group includes two members of the National Academy of Sciences and one member of the Institute of Medicine, each having mentored trainees during this most recent funding period, and several new members representing a broad spectrum of career stage and diversity. • A core curriculum in diabetes science required of all trainees to ensure that individuals with different backgrounds establish a standard knowledge base. • Training with a clinical context for PhD scientists as well as those with clinical degrees in order to inform translational efforts. • Clearly defined metrics of success that are monitored by a personalized Career Development Committee for each trainee. • A series of mechanisms to assess quality and effectiveness of the program as well as established procedures to take action in response to the results of these assessment tools. • A dynamically integrated short-term research training program operated in close collaboration with our NIDDK Diabetes Research Center. • Well-established mechanisms for enhancing diversity. Our trainees are productive, having published more than 250 papers that have been cited more than 8000 times in the past 10 years. They are successful in terms of obtaining grant support for their research that includes (in the past 10 years) two R01s, several R01 equivalents (in the EU), three K01s, two K12s, two KL2s, one K99/R00, several pilot and feasibility awards, awards from the American Diabetes Association and the American Heart Association, and others. They are successful in terms of achieving productive scientific careers since our trainees enter academics (in the past 10 years) at a rate ~50-100% greater (depending on degree) than the biomedical workforce based on data cited by NIH. Our integration of two programs has achieved synergies leading to improvements in the mentor pool, enhancements in recruitment and mentoring strategies, and expanded efforts to increase diversity that collectively perpetuate a culture of multidisciplinary training with a very high likelihood of exerting a sustained and powerful influence on diabetes research.

 描述（由申请人提供）： 这一竞争性更新申请代表了华盛顿大学两个成功的糖尿病研究培训项目DK 007120（位于医学系）和KD 007296（位于病理学和免疫学系）合并为一个名为糖尿病和相关代谢疾病（DK 007120）的单一项目。35年来，这两个T32项目培养了大量的生物医学科学家，他们对糖尿病产生了重要的见解。为了继续培养优秀的科学家和医生，能够开发新的方法来解决糖尿病及其并发症的显着增加，我们已经将这两个长期计划整合为一个。这个合并计划的目标是提供指导的专业知识，跨越模型系统的结果研究在一个培育，结构化的环境，将产生独立的糖尿病科学家可能会改变糖尿病及其并发症的研究景观。该计划由两个具有互补技能的PI指导，一个在免疫学方面，另一个在代谢方面，以促进免疫代谢新兴领域的培训机会。合并后的项目代表了华盛顿大学唯一一个由NIH支持的糖尿病研究博士后培训机制。 该计划正在不断发展，以回应我们对其有效性的持续评估，我们的学员的需求，以及糖尿病研究的动态性质。它是多学科和面向团队的。我们建议继续培训医学博士，医学博士，博士科学家2-3年，通过一个结构化的计划，利用众多的优势，包括但不限于：·一个特殊的池29导师专注于糖尿病。这些科学家正在进行基本机制的研究，T1翻译原理的证明，T2/T3翻译到患者和实践，以及T3/T4翻译到实践和人群。该小组包括国家科学院的两名成员和医学研究所的一名成员，每个人都在最近的资助期间指导了学员，还有几名新成员代表了广泛的职业阶段和多样性。 糖尿病科学的核心课程要求所有学员，以确保不同背景的个人建立一个标准的知识基础。·为博士科学家以及具有临床学位的科学家提供临床背景培训， 为翻译工作提供信息。 ·明确定义的成功指标，由个性化的职业发展委员会为每位学员进行监控。·一系列评估方案质量和有效性的机制，以及根据这些评估工具的结果采取行动的既定程序。·与我们的NIDDK糖尿病研究中心密切合作的动态整合短期研究培训计划。完善的促进多样性的机制。 我们的学员是富有成效的，发表了250多篇论文，在过去的10年中被引用超过8000次。他们成功地获得了研究资助，包括（在过去10年中）两个R 01，几个R 01等效物（在欧盟），三个K 01，两个K12，两个KL 2，一个K99/R 00，几个试点和可行性奖，美国糖尿病协会和美国心脏协会的奖项等。他们在实现生产性科学事业方面是成功的，因为我们的学员进入学术界（在过去10年中）的速度约50-100%（取决于学位）比生物医学劳动力根据NIH引用的数据。我们的两个项目的整合实现了协同效应，从而改善了导师库，增强了招聘和指导策略，并扩大了增加多样性的努力，共同延续了多学科培训的文化，很有可能对糖尿病研究产生持续和强大的影响。