DOSE- AHF

剂量-AHF

• 批准号: 8173624
• 负责人: Elizabeth O. Ofili
• 金额: $ 12.9万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173624
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Creatinine; Diuretics; Dose; Double-Blind Method; Drug Delivery Systems; Funding; Grant; Hour; Infusion procedures; Institution; Intravenous Bolus; Patients; Pharmacists; Randomized; Research; Research Personnel; Resources; SK-Furosemide; Source; Testing; United States National Institutes of Health; Visual; abstracting; analog; arm; randomized trial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Abstract of project: DOSE was a multicenter randomized trial that tested the effects of high intensification diuretic therapy verses low intensification therapy with Lasix. The delivery of the drug was by IV bolus or continual infusion. The double blinded study did not allow anyone except the pharmacist to know randomization arm. The primary endpoint was the change in creatinine from randomization to 72 hours and the patient global well being assessment by Visual Analog Scale over the 72 hour project.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 项目摘要： DOSE是一项多中心随机试验，测试了Lasix高强化利尿治疗与低强化治疗的效果。药物通过静脉推注或持续输注给药。 双盲研究不允许除药剂师之外的任何人知道随机分组。主要终点是从随机分组到72小时的肌酐变化和72小时项目期间通过视觉模拟量表进行的患者总体健康评估。