Liver Cancer Control Interventions for Asian Americans

描述(申请人提供)：1992-2000年间，在所有癌症类型中，肝癌的五年生存率低于10%，具有发病率年增长率最高的特点(3.9%)，而大多数其他癌症的发病率下降。男性肝癌发病率最高的是越南人(41.8/10万)，女性发病率最高的是韩国人(10.0/10万)；苗族男性发病率为25.7/10万，女性发病率为8.8/10万，介于其他两组之间。相比之下，非西班牙裔白人的可比发病率要低得多：(男性，3.7/10万；女性，1.5/10万)。这些比率表明，与乙肝相关的肝癌是影响亚裔美国人的最严重的癌症健康差距。这三个亚裔群体中的每一个都将是题为“针对亚裔美国人的肝癌控制干预”的P01的重点。这个P01由3个项目组成：#1“促进越南成年人的乙肝筛查”；#2“苗族成年人基于社区的乙肝干预措施”；以及#3“在韩国教会的信徒中增加乙肝筛查”。这些项目之间的协同作用体现在：所有项目都专注于相同的因变量：提高18岁-成年人的乙肝血清学检测率；使用健康行为框架；采取干预措施，比较干预条件和控制条件之间的效果；通过国家癌症研究所的亚裔美国人癌症意识研究和培训网络，拥有共同工作5年以上的研究负责人；以及2个支持核心：生物统计学和方法论。我们的目标是：(1)开展以社区为基础的研究干预，重点是降低这3个亚裔美国人中由乙肝引起的肝癌发病率和死亡率；(2)跨项目分析数据和经验教训；(3)与NCI、种族领袖、高危人群和专业受众报告进展并分享研究结果。如果这些目标和这三个项目中每个项目的具体目标都能实现，我们预计这项研究与公共卫生的相关性将包括关于基于社区的干预措施降低由乙肝引起的肝癌死亡率的有效性的第一批经验性数据。

DESCRIPTION (provided by applicant): Between 1992-2000 among all cancer types, liver cancer, with its 5-year survival rate of less than 10 percent, has the distinction of having the highest annual percent increase in incidence (3.9 percent), while the incidence for the majority of other cancers declined. The highest male incidence rate of liver cancer is among Vietnamese (41.8/100,000), and the highest female incidence is among Koreans (10.0/100,000); for Hmong, the male incidence rate of 25.7/100,000 and the female incidence rate of 8.8/100,000 is intermediate between these other two groups. By contrast, the comparable incidence rates for non-Hispanic White incidence are substantially less: (male, 3.7/100,000; female, 1.5/100,000). These rates indicate that hepatitis-B related liver cancer represents the most drastic cancer health disparity affecting Asian Americans. Each of these 3 Asian groups will be the focus of this P01 entitled, "Liver Cancer Control Interventions for Asian Americans." This P01 is comprised of 3 projects: #1 "Promoting Hepatitis B Screening for Vietnamese Adults"; #2 "Community-based Hep B Interventions for Hmong Adults"; and #3 "Increasing Hep B Screening Among Korean Church Attendees." Synergy among these projects is exemplified by: having all projects focused on the same dependent variable: increasing hepatitis B serological testing rates among adults, ages 18-64; using the Health Behavior Framework; having interventions that compare effects between intervention and control conditions; having research leaders who have worked over 5 years together through the NCI's Asian American Network for Cancer Awareness Research and Training; and 2 supporting cores: Biostatistics, and Methodology. Our goals are to: (1) Conduct community-based research interventions, focused on reducing hepatitis B-induced liver cancer morbidity and mortality within these 3 Asian American populations; (2) Analyze data and lessons across projects; and (3) Report progress and share findings with the NCI, ethnic leaders, populations-at-risk and professional audiences. If these goals and the specific aims of each of these three projects are achieved, we expect the relevance of this research to public health to include the first empirically derived data on the effectiveness of community based interventions to reduce hepatitis B-induced liver cancer mortality.