UCL: Bridging disciplines in multi-scale, multi-dimensional and time-series biomedical imaging

UCL：连接多尺度、多维和时间序列生物医学成像学科

• 批准号: G0502254/1
• 负责人: David Hawkes
• 金额: $ 41.57万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0502254%2F1
• 关键词: UCL; Bridging; disciplines; multi; scale

Imaging technologies are allowing us to probe the shape and function of the organs and structures that make up the human body. This can be done without harming the patient in any way. These technologies allow us to monitor treatment and guide therapies to where they are most needed. The 3D imaging techniques such as X-ray CT and MRI have only been around for 30 years yet in that time they have transformed healthcare. In recent years there have been significant advances in extending imaging methods, in particular optical techniques, to investigate the function of living cells that make up the human body and the interactions between the molecules that govern the functions of these cells. The level of detail provided by these images covers 6 orders of magnitude, often in 3D. This has created a challenge to find ways to understand how to relate relevant information across this wide range of spatial scale. This is required in order to better understand the function and interactions of the body?s organs, and their constituent cells, together with the molecular interactions that control their function in health and disease. Many of these imaging technologies also provide time varying information so that dynamic processes can be observed and measured. While these ?movies? provide invaluable information on dynamic and time changing processes that are so important in understanding normal metabolic function and disease, their analysis provides particularly difficult computational and mathematical challenges. This programme will bring together some of the world?s leading physical scientists, mathematicians, life scientists and clinicians to exploit these opportunities to establish research programmes to better understand the functioning of the human body in health and disease and ultimately to devise and test new therapies that result from this better understanding.

成像技术使我们能够探测组成人体的器官和结构的形状和功能。这可以在不伤害病人的情况下完成。这些技术使我们能够监测治疗情况，并将治疗方法引导到最需要的地方。像x射线CT和MRI这样的3D成像技术只有30年的历史，但它们已经改变了医疗保健。近年来，在扩展成像方法，特别是光学技术方面取得了重大进展，以研究构成人体的活细胞的功能以及控制这些细胞功能的分子之间的相互作用。这些图像提供的细节水平涵盖6个数量级，通常是3D的。这就提出了一个挑战，即找到理解如何在如此广泛的空间尺度上关联相关信息的方法。这是为了更好地了解身体的功能和相互作用所必需的。人体器官及其组成细胞，以及控制其健康和疾病功能的分子相互作用。许多成像技术还提供时变信息，以便观察和测量动态过程。而这些电影？提供关于动态和时间变化过程的宝贵信息，这些信息对于理解正常代谢功能和疾病非常重要，它们的分析提供了特别困难的计算和数学挑战。这个节目将把世界上的一些人聚集在一起。让顶尖的物理科学家、数学家、生命科学家和临床医生利用这些机会建立研究方案，以更好地了解人体在健康和疾病中的功能，并最终设计和测试由此产生的新疗法。