Genetic susceptibility to a deficit in context processing across the schizophrenia / bipolar disorder diagnostic divide.

跨越精神分裂症/双相情感障碍诊断鸿沟的背景处理缺陷的遗传易感性。

• 批准号: G0601635/1
• 负责人: James Walters
• 金额: $ 34.5万
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0601635%2F1
• 关键词: Genetic; susceptibility; deficit; context; processing

Schizophrenia and bipolar disorder are debilitating mental illnesses which affect around 2% of the population. Research suggests that deficits in higher mental processes (cognition) are common to schizophrenia and bipolar disorder. Several genes that increase risk for schizophrenia also increase risk for bipolar disorder. These findings reflect clinical experience where many patients present with symptoms of both disorders and suggest it may be more productive to study people with symptoms of both disorders rather than separately as is the tendency in current research.This project, conducted by a research psychiatrist, aims to examine a facet of cognition, context processing; the ability to notice the setting in which an event occurs. Using a novel test context processing will be investigated in people with symptoms of both schizophrenia and bipolar disorder. Two risk genes for schizophrenia and bipolar disorder will be investigated to see it they predict performance on the test.If people with schizophrenia AND bipolar disorder show this cognitive deficit and the risk genes increase the chances of showing such deficits this will have implications for the classification of these mental disorders as well as informing research into the causes and potential treatment of these deficits in severe mental illness.

精神分裂症和双相情感障碍是使人衰弱的精神疾病，影响约2%的人口。研究表明，精神分裂症和双相情感障碍患者在高级心理过程（认知）方面存在缺陷。一些增加精神分裂症风险的基因也会增加双相情感障碍的风险。这些研究结果反映了临床经验，许多患者同时存在两种疾病的症状，并建议研究两种疾病的症状，而不是单独研究，这可能是更有成效的，因为这是目前研究的趋势。这个项目，由研究精神病学家进行，旨在研究认知的一个方面，背景处理;注意到事件发生的环境的能力。使用一种新的测试上下文处理将在精神分裂症和双相情感障碍的症状的人进行调查。精神分裂症和双相情感障碍的两个风险基因将被调查，看看他们预测测试的表现。如果精神分裂症和双相情感障碍的人表现出这种认知缺陷，风险基因增加了表现出这种缺陷的机会，这将对这些精神障碍的分类产生影响，并为严重精神疾病中这些缺陷的原因和潜在治疗提供信息。