Imaging and Information Technology Core

核心B包括成像和信息技术组件。成像技术组件的主要功能是为每个项目的研究人员提供最先进的显微镜仪器，以及显微镜系统、图像处理软件和图像分析程序的培训和咨询。核心的仪器包括原子力（AFM）、会聚荧光、共聚焦、福斯特共振能量转移（FRET）、全内反射荧光（TIRF）和多光子显微镜的成像系统。额外的组件和实验室空间将允许研究人员在系统上维持细胞培养环境条件，以延长活细胞和组织的成像时间。该核心部分提供的服务将包括协调仪器的使用，对仪器和成像软件的使用进行培训，以及仪器的日常管理，进行图像分析以及就图像采集和处理提供咨询。信息技术组件的主要功能是为该计划的计算、数据存储和分析软件需求提供服务。与A中心协调，B中心将维护一个公共网站，用于分发研究新闻和项目活动。信息技术组件还将监督集中数据库管理，包括大规模图像存储环境，为成像设施的软件更新需求提供支持，并为系统分析和定制编程提供资源。此外，核心的信息技术部分将维护和协调所有核心设备的调度计划，以跟踪设备的使用情况。按照规定，核心的成像和信息组件将协调维护一个网站，以安排核心设备的使用，并为系统的最佳运行提供培训和信息文件。核心人员将包括主任、联合主任、两名技术人员和一名新闻专家。他们的职责包括为用户提供培训和建议，仪器和图像分析软件的日常操作，以及保持基础设施处于最佳状态。所有项目都可根据需要提供使用任何系统的培训。此外，每年将举行两次正式培训课程，以更新任何能力和改进。主任将确保核心人员掌握仪器操作、软件和应用的最新知识。

Core B consists of imaging and Information technology components. The primary function of the Imaging Technology Component is to provide the investigators of each of the projects access to state of the art microscope instruments, as well as training, and consultation on the microscopy systems, image processing software, and image analysis procedures. The instruments of the Core consist of imaging systems equipped for atomic force (AFM), epifluorescence, confocal, Forster resonance energy transfer (FRET), total internal reflection fiuorescence (TIRF), and multiphoton microscopy. Additional components and laboratory space will allow investigators to maintain cell culture environmental conditions on the systems for prolonged imaging of live cells and tissues. The services provided by this component of the Core will consist of coordinating the use of the instruments, training on the use of the instruments and imaging software, as well as, day-to-day management of the instruments, performing image analyses and counseling on image acquisition and processing. The principal function of the Information Technology Component will be to service the computational, data storage and analysis software needs of the Program. In coordination with Core A, Core B will maintain a public website for distribution of research news and program activities. The Information Technology Component will also oversee centralize database management that will Include large scale image storage environments, provide for the update software needs of the Imaging Facilities, and provide a resource for system analysis and custom programming. In addition, the Information Technology component of the Core will maintain and coordinate a scheduling program for all Core equipment to track equipment usage. In accordance, the imaging and information components of the Core will coordinate the maintenance of a website for scheduling Core equipment use and for providing training and informational documents for the optimal operation of the systems. The Core personnel will consist of the director, co-director, two technicians and an information specialist. Their duties will consist of training and advising the users, day-today operation of instruments and image analysis software and maintaining the infrastructure in optimal condition. Training for use of any of the systems will be available on demand to all projects. Also, 2 formal training sessions will be held yeariy as an update on any capabilities and improvements. The Director will ensure that Core personnel maintain current knowledge of instrumention operation, software and applications.