Superconducting Gradient Coil for Targeted Therapy by Micro-particle Navigation

描述(由申请人提供)：我们的提案引入了有助于设计和制造三轴磁梯度线圈的新技术，这些线圈用于体内导航人体动脉中的载药颗粒，可通过核磁共振扫描仪进行追踪。开发一种实用的体内粒子导航器可以带来非常有效的微创医疗，也许最重要的是将药物输送到癌症组织。蒙特利尔大学理工学院纳米机器人实验室(NLEPM)利用核磁共振硬件演示了基于图像的粒子导航原理。NLEPM是我们拟议工作的合作者，他最近的工作表明，需要数百mT/m的磁场梯度强度来导航可用作药物载体的微粒。我们提出的第二阶段工作旨在设计和制造全功能的超导梯度线圈，可以达到500mT/m，可以用于中型动物的微小粒子导航。 与公共健康相关：我们的提案引入了有助于设计和制造三轴磁梯度线圈的新技术，这些线圈用于体内导航人体动脉中的载药颗粒，可通过核磁共振扫描仪进行追踪。开发一种实用的体内粒子导航器可以带来非常有效的微创医疗，也许最重要的是将药物输送到癌症组织。在第二阶段计划中，我们将建造和调试一个梯度强度为500mT/m的全功能超导梯度线圈，以演示微型粒子在中型动物中的导航。

DESCRIPTION (provided by applicant): Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. The NanoRobotics Laboratory Ecole Polytechnique Montreal (NLEPM) has demonstrated principles of image-based particle navigation by use of MRI hardware. Recent work by NLEPM, who is a collaborator in our proposed work, has indicated a need for magnetic field gradient strength of hundreds of mT/m to navigate micro-particle that can be used as carries of drugs. Our proposed Phase II work intends to design and build fully functional superconducting gradient coils that can achieve 500 mT/m, which can be used in Navigation of micro-particles in midsize animals. PUBLIC HEALTH RELEVANCE: Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. In the Phase II program we will build and commission a fully functional superconducting gradient coil with gradient strength of 500 mT/m to demonstrate navigation of micro-particles in midsize animals.