Superconducting Gradient Coil for Targeted Therapy by Micro-particle Navigation

用于微粒导航靶向治疗的超导梯度线圈

• 批准号: 8614532
• 负责人: Shahin Pourrahimi
• 金额: $ 33.19万
• 依托单位: SUPERCONDUCTING SYSTEMS, INC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8614532
• 关键词: Superconducting; Gradient; Coil; Targeted; Therapy

DESCRIPTION (provided by applicant): Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. The NanoRobotics Laboratory Ecole Polytechnique Montreal (NLEPM) has demonstrated principles of image-based particle navigation by use of MRI hardware. Recent work by NLEPM, who is a collaborator in our proposed work, has indicated a need for magnetic field gradient strength of hundreds of mT/m to navigate micro-particle that can be used as carries of drugs. Our proposed Phase II work intends to design and build fully functional superconducting gradient coils that can achieve 500 mT/m, which can be used in Navigation of micro-particles in midsize animals. PUBLIC HEALTH RELEVANCE: Our proposal introduces novel technologies that facilitate designing and manufacturing three- axis magnetic gradient coils for in vivo navigation of drug carrying particles in human arteries that are traceable by an MRI scanner. Developing a practical in vivo particle navigator can lead to very effective minimally invasive medical treatments, perhaps most importantly drug delivery to cancerous tissue. In the Phase II program we will build and commission a fully functional superconducting gradient coil with gradient strength of 500 mT/m to demonstrate navigation of micro-particles in midsize animals.

描述（由申请人提供）：我们的提案引入了新技术，有助于设计和制造三轴磁梯度线圈，用于人体动脉中载药颗粒的体内导航，可通过MRI扫描仪进行追踪。开发一种实用的体内粒子导航器可以导致非常有效的微创医疗，也许最重要的是将药物输送到癌组织。NanoRobotics Laboratory Ecole Polytechnique Montreal（NLEPM）已经通过使用MRI硬件展示了基于图像的粒子导航原理。NLEPM最近的工作表明，需要数百mT/m的磁场梯度强度来导航可用作药物载体的微粒。我们提出的第二阶段工作旨在设计和建造功能齐全的超导梯度线圈，可达到500 mT/m，可用于中型动物的微粒子导航。 公共卫生关系：我们的提案引入了新技术，这些新技术有助于设计和制造三轴磁梯度线圈，用于人体动脉中可通过MRI扫描仪追踪的载药颗粒的体内导航。开发一种实用的体内粒子导航器可以导致非常有效的微创医疗，也许最重要的是将药物输送到癌组织。在第二阶段计划中，我们将建造并调试一个全功能的超导梯度线圈，梯度强度为500 mT/m，以演示中型动物中微粒的导航。