Sleep Patterns as a risk factor for disease in the Hispanic Community Health Stud

西班牙裔社区健康研究中心的睡眠模式是疾病的危险因素

• 批准号: 7985139
• 负责人: Sanjay R Patel
• 金额: $ 82.34万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2010-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7985139
• 关键词: Accidents; Acculturation; Address; Adult; Affect; African American; Ancillary Study; Animal Model; Anxiety; Behavior; Belief; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Caucasians; Caucasoid Race; Characteristics; Circadian Rhythms; Communities; Community Health; Coronary; Data; Data Analyses; Desire for food; Development; Diabetes Mellitus; Diet; Disease; Disease Outcome; Drops; Electricity; Evaluation; Event; Fostering; Future; Habits; Health; Health Status; Health behavior; Heart Diseases; Heterogeneity; Hispanic Americans; Hispanics; Home environment; Hormones; Hour; Human; Hypertension; Industrialization; Inflammation; Internet; Lead; Life; Life Style; Lipids; Literature; Measurement; Measures; Mediating; Metabolic syndrome; Mexican Americans; Minority; Minority Groups; Moods; Napping; Neighborhoods; Obesity; Outcome; Participant; Patient Self-Report; Pattern; Performance at work; Phase; Phenotype; Polysomnography; Population; Populations at Risk; Positioning Attribute; Prevalence; Psychological Factors; Psychosocial Factor; Public Health; Reliance; Research; Research Priority; Resources; Risk; Risk Factors; Role; Sampling; Schedule; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Social Network; Societies; Socioeconomic Status; Stress; Subgroup; Surgeon; Surveys; Testing; Time; Variant; Work; Workplace; Wrist; actigraphy; base; cardiovascular disorder prevention; cardiovascular disorder risk; circadian pacemaker; cohort; community health study; ethnic minority population; falls; follow-up; health disparity; high risk; improved; insight; insulin sensitivity; low socioeconomic status; mortality; novel; public health relevance; research study; shift work; social; trend

DESCRIPTION (provided by applicant): With technological advances such as electricity and the internet, humans are increasingly living in a 24-hour society that has led to substantial changes in sleeping patterns including a 2 hour reduction in average sleep duration among US adults over the past 80 years. Preliminary studies suggest that altered sleep including reductions in amount, quality, and regularity are associated with up to a 3-fold increase in the risk of cardiovascular disease (CVD) and CVD risk factors such as obesity, diabetes, and hypertension. Thus, effects on sleep may reflect one of the mechanisms by which a 21st century lifestyle predisposes to heart disease. However, the existing literature that has addressed the role of sleep largely has been limited by the lack of objective measurements of sleep and has not included a representative sample of ethnic minorities, who are at greatest risk for poor sleep. In the proposed ancillary study to the Hispanic Community Health Study (HCHS), a large US community based cohort of four Hispanic-American groups, we aim to fill this gap by collecting objective measurements of sleep patterns in 2000 study participants who are already undergoing rigorous assessment of a broad range of CVD risk factors and outcomes. Capitalizing on the HCHS resource and expanding assessments to include objective sleep pattern measurements, will provide unique and efficient opportunities to: (1) assess the prevalence of altered sleep patterns in Hispanic-Americans and assess variability among ethnic subgroups; (2) define the importance of psychosocial factors such as socioeconomic status, factors in the home and work environment and mood as well as cultural factors specific to Hispanic-Americans such as acculturation, familism, and beliefs about sleep, in predicting abnormal sleep patterns; and (3) assess the association between poor sleep and relevant cardiovascular health outcomes including obesity, hypertension, diabetes, and heart disease in Hispanic-Americans. The proposed new data and analyses will help clarify the role of sleep disorders in the development of CVD while also providing insight into the factors most responsible for poor sleep habits in the largest minority group in the US, thus establishing a framework for the development of strategies to improve sleep as a novel treatment for CVD prevention in this at risk population. PUBLIC HEALTH RELEVANCE: Over the past century, the amount of time that people spend sleeping has steadily dropped and this appears to be particularly true in minority groups. Prior research has suggested poor sleep may be a risk factor for heart disease, obesity, and diabetes. In this study, we propose to perform a comprehensive evaluation of sleep habits in 2,000 Hispanic-Americans in order to understand the factors that influence sleep behaviors as well as to better understand how poor sleep may affect heart disease and related disorders.

随着电力和互联网等技术的进步，人类越来越多地生活在一个24小时的社会中，这导致睡眠模式发生了重大变化，包括过去80年来美国成年人的平均睡眠时间减少了2小时。初步研究表明，睡眠的改变，包括数量，质量和规律性的减少，与心血管疾病（CVD）和CVD风险因素（如肥胖，糖尿病和高血压）的风险增加高达3倍有关。因此，对睡眠的影响可能反映了21世纪世纪生活方式易患心脏病的机制之一。然而，现有的文献主要讨论了睡眠的作用，但由于缺乏对睡眠的客观测量而受到限制，并且没有包括少数民族的代表性样本，这些少数民族最有可能出现睡眠不佳。在西班牙裔社区健康研究（HCHS）的辅助研究中，一个由四个西班牙裔美国人群体组成的大型美国社区队列，我们的目标是通过收集2000名研究参与者的睡眠模式的客观测量来填补这一空白，这些参与者已经接受了广泛的CVD风险因素和结果的严格评估。利用HCHS资源并将评估扩展到包括客观睡眠模式测量，将提供独特和有效的机会：（1）评估西班牙裔美国人睡眠模式改变的患病率并评估种族亚组之间的差异;（2）确定社会心理因素的重要性，如社会经济地位，家庭和工作环境和情绪因素以及西班牙裔美国人特有的文化因素，如文化适应，家庭主义和对睡眠的信念，在预测异常的睡眠模式;以及（3）评估西班牙裔美国人睡眠不佳与相关心血管健康结果之间的关系，包括肥胖、高血压、糖尿病和心脏病。提出的新数据和分析将有助于澄清睡眠障碍在CVD发展中的作用，同时也为美国最大的少数群体中最负责任的睡眠习惯不良的因素提供了洞察力，从而建立了一个框架，用于制定改善睡眠的策略，作为风险人群中CVD预防的新治疗方法。 公共卫生相关性：在过去的世纪里，人们的睡眠时间一直在稳步下降，这在少数群体中尤其如此。此前的研究表明，睡眠不足可能是心脏病、肥胖和糖尿病的危险因素。在这项研究中，我们建议对2,000名西班牙裔美国人的睡眠习惯进行全面评估，以了解影响睡眠行为的因素，并更好地了解睡眠不良如何影响心脏病和相关疾病。