Pacific NorthWest Regional Center of Excellence (PNWRCE)
西北太平洋区域卓越中心 (PNWRCE)
基本信息
- 批准号:7912529
- 负责人:
- 金额:$ 81.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-17 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The goal of this application is to establish the Pacific Northwest Regional Center of Excellence (PNWRCE) in NIAID Region X. The two inter-related but distinct PNWRCE themes that we have selected reflect not only the scientific strengths at our institutions but also the unmet needs that we perceive are absent in the NIAID biodefense and emerging disease program. The first theme "Identification of Age-Related Defects in the Immune System to Develop Vaccines and Supplemental Therapies" will include two projects. The overall goal of these projects is to develop new vaccines and immune supplemental therapies for immune vulnerable populations such as aged individuals. The first project a P01 will investigate the hypothesis that certain unifying manipulations can be performed to increase T cell immunity in immune vulnerable populations to a broad group of pathogens. The second project will develop a novel and effective vaccine platform for safely immunizing both healthy and vulnerable populations against YFV. The second theme will center on "The use of systems biology, functional genomics and genetics to characterize pathogen-host response for biodefense and emerging disease organisms." This theme will include four projects with the overall goal of using systems approaches to identify new targets and therapeutics for Category A-C agents. The goal of the first project a P01 is to use systems approaches to identify common host susceptibility alleles and signaling circuitry that enhance highly pathogenic pneumonic viruses and Ebola virus replication and pathogenesis and to identify key cellular targets and immune correlates that influence severe disease outcomes. The goal of the second project a P01 is focused on defining innate immune mechanisms, therapeutic targets, and antiviral compounds that limit flavivirus infection and pathogenesis. The third project an R01 will use systems approaches to characterize Francisella mutants that exhibit either altered intracellular growth rates or induce cellular apoptosis. The last project an RO1 will use a combination of genetic, biochemical, and computational approaches to elucidate B. pseudomallei host pathogen response during both the septicemic as well as the intracellular phases of the disease.
STRATEGIC MANAGEMENT PLAN/CORE A: Strategic Plan and Management (Project SMP Leader, J. Nelson)
STRATEGIC MANAGEMENT PLAN/CORE A DESCRIPTION (provided by applicant): The PNWRCE is a Regional Center of Excellence (RCE) that includes the majority of the institutions in the Northwest including Oregon Health and Science University (OHSU), the University of Washington (UW), Pacific Northwest National Laboratory (PNNL), and the University of Idaho (Ul) as well as institutions outside our region such as the University of Arizona (UA), University of Wisconsin, the University of North Carolina at Chapel Hill, Washington University in St. Louis, the Memorial Sloan-Kettering Cancer Center in New York, and the Rocky Mountain Laboratories (NIAID) in Hamilton, Montana. The Center has a strong multidisciplinary character, exemplified by highly interactive Research Projects and associated Scientific Cores as well as Developmental Projects, Training Programs, and an Emergency Preparedness Program. A strong administrative and organizational structure is vital to the Center's ability to successfully carry out each of the functions of the center to promote synergy between programmatic elements. In this Core, we outline in detail our administrative structure, the role of the Director, Co-Director, Administrator, and Advisory Boards in managing Center activities. Clearly, the success of the Administrative Core is dependent upon its personnel, and we have assembled an experienced team of Directors and Administrators. We are also fortunate to have a Steering Committee and participants that are composed of highly regarded experts in the fields of virology, bacteriology and immunology, as well as proteomics and bioinformatics to provide guidance, selection of projects and career development awards to maintain the function, productivity, flexibility and excellence of the center. The Specific Aims of the Administrative Core are to: 1) Provide an organizational and programmatic structure to promote scientific interactions, research productivity, and training. 2) Provide oversight, planning, priority setting, and decision-making processes. 3) Ensure that the Center is compliant with IRB and IACUC issues. In addition the Administrative Core is tasked with ensuring that the Center continues to meet all criteria described in the NIAID Research Centers of Excellence in Biodefense and Emerging Disease Program and Review Guidelines, including a data sharing plan, state-of-the-art facilities, innovation, multidisciplinary involvement, thematic integration, and synergy among RCEs.
描述(由申请人提供):本申请的目标是在NIAID区域X建立太平洋西北地区卓越中心(PNWRCE)。我们选择的两个相互关联但不同的PNWRCE主题不仅反映了我们机构的科学优势,而且反映了我们认为NIAID生物防御和新兴疾病计划中缺乏的未满足的需求。第一个主题“识别免疫系统中与艾滋病相关的缺陷以开发疫苗和补充疗法”将包括两个项目。这些项目的总体目标是为老年人等免疫脆弱人群开发新疫苗和免疫补充疗法。第一个项目P01将研究这样一种假设,即可以进行某些统一的操作,以增加免疫脆弱人群对广泛病原体的T细胞免疫力。第二个项目将开发一种新型有效的疫苗平台,用于安全地对健康和脆弱人群进行YFV免疫接种。第二个主题将集中在“利用系统生物学,功能基因组学和遗传学来表征病原体-宿主反应的生物防御和新出现的疾病生物。“这个主题将包括四个项目,其总体目标是使用系统方法来确定A-C类药物的新靶点和治疗方法。第一个项目P01的目标是使用系统方法来识别增强高致病性肺炎病毒和埃博拉病毒复制和发病机制的常见宿主易感性等位基因和信号通路,并识别影响严重疾病结果的关键细胞靶点和免疫相关性。第二个项目P01的目标是定义先天免疫机制,治疗靶点和限制黄病毒感染和发病机制的抗病毒化合物。第三个项目R 01将使用系统方法来表征弗朗西斯菌突变体,这些突变体表现出细胞内生长速率的改变或诱导细胞凋亡。最后一个项目RO 1将使用遗传学、生物化学和计算方法的组合来阐明B。在败血症以及疾病的细胞内阶段期间,假鼻疽宿主病原体应答。
战略管理课程/核心A:战略规划和管理(SMP项目负责人,J.纳尔逊)
战略管理体系/核心A描述(申请人提供):PNWRCE是一个区域卓越中心(RCE),包括西北地区的大多数机构,包括俄勒冈州健康与科学大学(OHSU),华盛顿大学(UW),太平洋西北国家实验室(PNNL),和爱达荷州大学(Ul)以及我们地区以外的机构,如亚利桑那大学(UA)、威斯康星州大学、查佩尔山的北卡罗来纳州大学,圣路易斯的华盛顿大学、纽约的斯隆-凯特琳纪念癌症中心和蒙大拿州汉密尔顿的落基山实验室(NIAID)。该中心具有很强的多学科性质,高度互动的研究项目和相关的科学核心以及发展项目,培训计划和应急准备计划就是例证。一个强有力的行政和组织结构对于中心成功履行其各项职能以促进方案要素之间的协同作用的能力至关重要。在本核心文件中,我们详细介绍了我们的行政结构,主任、联合主任、行政人员和咨询委员会在管理中心活动中的作用。显然,行政核心的成功取决于其人员,我们已经组建了一个经验丰富的主任和行政人员团队。我们也很幸运有一个指导委员会和参与者,由病毒学,细菌学和免疫学领域的高度重视的专家组成,以及蛋白质组学和生物信息学,提供指导,选择项目和职业发展奖,以保持中心的功能,生产力,灵活性和卓越性。行政核心的具体目标是:1)提供一个组织和计划结构,以促进科学互动,研究生产力和培训。2)提供监督、规划、优先事项设定和决策流程。3)确保中心符合IRB和IACUC的要求。此外,行政核心的任务是确保该中心继续符合NIAID生物防御和新发疾病计划和审查指南卓越研究中心中描述的所有标准,包括数据共享计划,最先进的设施,创新,多学科参与,主题整合和RCE之间的协同作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAY A NELSON其他文献
JAY A NELSON的其他文献
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{{ truncateString('JAY A NELSON', 18)}}的其他基金
Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency and reactivation
人类巨细胞病毒对宿主造血祖细胞信号通路的失调调节潜伏期和重新激活
- 批准号:
10327944 - 财政年份:2017
- 资助金额:
$ 81.96万 - 项目类别:
Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation
人类巨细胞病毒对宿主造血祖细胞信号通路的失调,以调节移植过程中的潜伏期、重新激活和造血作用
- 批准号:
9753907 - 财政年份:2017
- 资助金额:
$ 81.96万 - 项目类别:
Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation
人类巨细胞病毒对宿主造血祖细胞信号通路的失调,以调节移植过程中的潜伏期、重新激活和造血作用
- 批准号:
10216629 - 财政年份:2017
- 资助金额:
$ 81.96万 - 项目类别:
HCMV miRNA regulation of host cell signaling in viral latency and hematopoiesis
HCMV miRNA 对病毒潜伏期和造血过程中宿主细胞信号传导的调节
- 批准号:
10216634 - 财政年份:2017
- 资助金额:
$ 81.96万 - 项目类别:
HCMV miRNA regulation of host cell signaling in viral latency and hematopoiesis
HCMV miRNA 对病毒潜伏期和造血过程中宿主细胞信号传导的调节
- 批准号:
9980281 - 财政年份:2017
- 资助金额:
$ 81.96万 - 项目类别:
Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency, reactivation, and hematopoiesis during transplantation
人类巨细胞病毒对宿主造血祖细胞信号通路的失调,以调节移植过程中的潜伏期、重新激活和造血作用
- 批准号:
9980274 - 财政年份:2017
- 资助金额:
$ 81.96万 - 项目类别:
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