A National Centre for Protein Kinase Profiling

激酶是人类存在的最大的酶家族。它们参与协调几乎所有的身体功能，它们的失调是许多疾病的原因或后果。因此，激酶已成为21世纪的主要药物靶点。十种阻止特定激酶起作用的药物已被批准用于临床，并对癌症的治疗产生了巨大影响，其中一种药物基本上治愈了一种以前会迅速致命的白血病。本申请的目的是获得资金，以维持和改进由我领导的MRC部门建立的一项新服务，该服务已被证明在加速该领域药物开发方面具有重要价值。

Kinases are the largest family of enzymes present in human beings. They are involved in co-ordinating almost all the body s functions and their deregulation is a cause or consequence of many diseases. For this reason, kinases have become the major drug targets of the 21st Century. Ten drugs that prevent particular kinases from working have been approved for clinical use and have had a huge impact on the treatment of cancer, including one drug that essentially cures a form of leukaemia that previously was rapidly fatal. The purpose of this application is to obtain funding to maintain and improve a novel service that has been set up by the MRC Unit that I direct and which has proved to be of great value in speeding up the development of drugs in this area.