A National Centre for Protein Kinase Profiling

国家蛋白激酶分析中心

• 批准号: MC_EX_G0800765
• 负责人: Philip Cohen
• 金额: $ 123.77万
• 依托单位: MRC Protein Phosphorylation and Ubiquitylation Unit
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_EX_G0800765
• 关键词: National; Centre; Protein; Kinase; Profiling

Kinases are the largest family of enzymes present in human beings. They are involved in co-ordinating almost all the body s functions and their deregulation is a cause or consequence of many diseases. For this reason, kinases have become the major drug targets of the 21st Century. Ten drugs that prevent particular kinases from working have been approved for clinical use and have had a huge impact on the treatment of cancer, including one drug that essentially cures a form of leukaemia that previously was rapidly fatal. The purpose of this application is to obtain funding to maintain and improve a novel service that has been set up by the MRC Unit that I direct and which has proved to be of great value in speeding up the development of drugs in this area.

激酶是存在于人类中的最大的酶家族。它们参与协调几乎所有的身体功能，它们的失调是许多疾病的原因或后果。因此，激酶已成为21世纪世纪的主要药物靶标。10种阻止特定激酶发挥作用的药物已被批准用于临床，并对癌症治疗产生了巨大影响，其中包括一种基本上治愈一种白血病的药物，这种白血病以前是迅速致命的。这项申请的目的，是为了获得拨款，以维持和改善由我领导的药物管制委员会小组设立的一项新服务，这项服务已证明对加快这方面的药物开发有很大的价值。

项目成果

Immune diseases caused by mutations in kinases and components of the ubiquitin system.

• DOI: 10.1038/ni.2892
• 发表时间: 2014-06
• 期刊: Nature immunology
• 影响因子: 30.5
• 作者: Cohen P